TABLE 3.

Treatment‐emergent adverse events.

	Arm A: (n = 3)		Arm B: (n = 3)		Arm C: (n = 6)		Arm D: (n = 5)
Category/adverse event	All grade (%)	Grade 3/4 (%)	All grade (%)	Grade 3/4 (%)	All grade (%)	Grade 3/4 (%)	All grade (%)	Grade 3/4 (%)
AE patients	3 (100.0)	2 (66.7)	3 (100.0)	3 (100.0)	6 (100.0)	4 (66.7)	5 (100.0)	3 (60.0)
Constitutional
Fever	1 (33.3)	0	2 (66.7)	0	3 (50.0)	0	1 (20.0)	0
Fatigue	0	0	3 (66.7)	0	2 (33.3)	0	1 (20.0)	0
Edema peripheral	0	0	1 (33.3)	0	2 (33.3)	0	2 (40.0)	0
Loss of appetite	1 (33.3)	0	1 (33.3)	1 (33.3)	2 (33.3)	0	1 (20.0)	0
Hematological/laboratory
Leucopenia	2 (66.7)	1 (33.3)	3 (100.0)	1 (33.3)	4 (66.7)	3 (50.0)	4 (80.0)	0
Neutropenia	3 (100.0)	2 (66.7)	2 (66.7)	1 (33.3)	4 (66.7)	2 (33.3)	4 (80.0)	1 (20.0)
Thrombocytopenia	1 (33.3)	1 (33.3)	2 (66.7)	1 (33.3)	5 (83.3)	1 (16.7)	3 (60.0)	1 (20.0)
Anemia	2 (66.7)	1 (33.3)	3 (100.0)	1 (33.3)	5 (83.3%)	0	4 (80.0)	1 (20.0)
Aspartate Aminotransferase high	0	0	3 (100.0)	0	3 (50.0)	0	0	0
Glutamic‐pyruvic transaminase high	1 (33.3)	0	3 (100.0)	0	1 (16.7)	0	1 (20.0)	0
Alkaline phosphatase high	1 (33.3)	0	2 (66.7)	0	3 (50.0)	0	1 (20.0)	0
D‐dimer high	1 (33.3)	0	1 (33.3)	0	1 (16.7)	0	1 (20.0)	0
Gastrointestinal
Nausea	0	0	1 (33.3)	0	2 (33.3)	0	0	0
Vomiting	1 (33.3)	0	1 (33.3)	0	3 (50.0)	0	1 (20.0)	0
Oral mucositis	0	0	0	0	1 (16.7)	0	0	0
Diarrhea	0	0	1 (33.3)	0	0	0	3 (60.0)	0
Abdominal pain	0	0	1 (33.3)	0	2 (33.3)	0	0	0
Constipation	0	0	0	0	3 (50.0)	0	1 (30.0)	0
Ascitic fluid		1 (33.3)
Other adverse events
Sinus bradycardia	0	0	0	0	4 (66.7)	0	1 (20.0)	0
Palpitation	0	0	0	0	2 (33.3)	0	0	0
Chest distress	0	0	0	0	4 (66.7)	0	0	0
Deep venous thrombosis	1 (33.3)	0	0	0	0	0	0	0
Rash	1 (33.3)	0	1 (33.3)	2 (33.3)	2 (33.3)	0	1 (20.0)	0
Interstitial lung disease	0	0	0	2 (33.3)	2 (33.3)	0	0	0
Splenic infarction	0	0	0	0	1 (16.7)	0	0	0