Table 2C.

Univariable and multivariable cox proportional hazard models for serum CAR in HFrEF plus HFmrEF heart failure.

	Univariable		Multivariable
	HR (95% CI)	p	HR (95% CI)	p
Age	1.027 (1.018, 1.036)	0.001	1.022 (1.011, 1.032)	0.001
Sex (reference: male)	1.041 (0.839, 1.291)	0.717	1.049 (0.846, 1.386)
NYHA class (reference: class IV)	0.438 (0.356, 0.538)	0.001	0.547 (0.436, 0.685)	0.001
Heart rate	1.005 (1.008, 1.013)	0.015	1.004 (1.001, 1.007)
SBP	0.997 (0.991, 0.997)	0.001	1.001 (0.993, 1.009)
DBP	0.984 (0.977, 0.991)	0.001	0.989 (0.978, 1.010)
CRP	1.010 (1.008, 1.013)	0.001	1.012 (1.005, 1.019)	0.031
Albumin	0.935 (0.912, 0.959)	0.001	0.952 (0.920, 0.985)	0.005
ALT	1.003 (1.002, 1.004)	0.001	1.001 (1.000, 1.003)
AST	1.004 (1.002, 1.005)	0.001	1.004 (1.002, 1.009)	0.046
TC	0.811 (0.729, 0.903)	0.001	0.927 (0.896, 0.997)
Creatinine	1.004 (1.003, 1.005)	0.001	1.001 (0.998, 1.002)
Uric acid	1.002 (1.000, 1.003)	0.001	1.001 (1.000, 1.005)	0.001
Chlorine	0.936 (0.914, 0.958)	0.001	0.972 (0.949, 0.997)	0.025
WBC	1.057 (1.032, 1.083)	0.012	0.998 (0.945, 1.004)
Hemoglobin	0.991 (0.986, 0.995)	0.001	0.994 (0.989, 0.998)	0.021
LgBNP	6.073 (3.965, 9.302)	0.001	2.695 (1.649, 4.286)	0.001
CAR	1.004 (1.003, 1.005)	0.001	1.007 (1.001, 1.010)	0.019

Corrected for age, NYHA class, heart rate, SBP, DBP, CRP, albumin, ALT, AST, TC, creatinine, uric acid, chlorine, WBC, hemoglobin, lgBNP.

HR, hazard ratio; CI, confidence interval; CAR, c-reactive protein-to-albumin ratio; NYHA, New York Heart Association; SBP, systolic blood pressure; DBP, diastolic blood pressure; CRP, c-reactive protein; ALT, alanine transaminase; AST, aspartate transaminsae; TC, total cholesterol; WBC, white blood cells; BNP, brain natriuretic peptide; HFrEF, heart failure with reduced ejection fraction; HFmrEF, heart failure with mildly reduced ejection fraction.