Table 1. Repeated metabolic biomarkers related to AMD.

Metabolite name	Hits	HMDB	PubChem	Samples	KEGG
PG(16:0/20:4(5Z,8Z,11Z,14Z))	2	HMDB0010580	24779550	Plasma	–
PC(18:0/20:4(5Z,8Z,11Z,14Z))	2	HMDB0008048	16219824	Plasma	–	1-stearoyl-2–2-arachidonoyl-3-sn-glycero-4–3-phosphocholine
Acetate	2	HMDB0000042	176	Plasma, serum	C00033
Adenosine	2	HMDB0000050	60961	Plasma	C00212
Alanine	2	HMDB0000161	5950	Plasma, serum	C00041
Carnitine	2	HMDB0000062	2724480	Plasma. aqueous humour	C00318
Citrate	2	HMDB0000094	311	Urine, plasma, serum	C00158
Creatine	2	HMDB0000064	586	Plasma, aqueous humour	C00300
Cortexolone	2	HMDB0000015	53477676	Plasma
Glutamine	4	HMDB0000641	5961	Plasma, serum, plasma	C00064
Glycine	2	HMDB0000123	750	Urine, plasma, serum	C00037
Histidine	3	HMDB0000177	6274	Plasma, serum	C00135
Hypoxanthine	2	HMDB0000157	790	Plasma, serum	C00262
Lysine	2	HMDB0000182	5962	Urine, plasma	C00047
Maltose	2	HMDB0037138	439341	Plasma, serum	C00897
N-acetylasparagine	2	HMDB0006028	99 715	Plasma	–
Phenylalanine	3	HMDB0000159	6140	Plasma, aqueous humour, serum	C00079
Proline	3	HMDB0000162	145742	Plasma, aqueous humour	C00148
Pyroglutamic acid	2	HMDB0000267	7405	Plasma	C01879
Pyruvate	3	HMDB0000243	1060	Plasma, urine, serum	C00022
Tyrosine	3	HMDB0000158	6057	Plasma, urine, serum	C00082
Valine	3	HMDB0000883	6287	Urine, plasma, serum	C00183
DG(18:1(9Z)/18:2 (9Z,12Z)/0:0)	2	HMDB0007219	9543722	Plasma	–	1-oleoyl-2–2-linoleoyl-3-sn-glycerol
DG(18:1(9Z)/20:4 (5Z,8Z,11Z,14Z)/0:0)	2	HMDB0007228	9543786	Plasma	–	1-oleoyl-2–2-arachidonoyl-3-sn-glycerol

AMD, age-related macular degeneration; HMDB, Human Metabolome DatabaseKEGG, Kyoto Encyclopaedia of Genes and Genomes