Table 5. Intracellular Activity of 4-Alkoxyquinoline 8t in Murine Macrophages Model of TB Infectiona.
| Entry | Log10 CFU/well (Mean ± SD) |
|---|---|
| Early Control | 3.28 ± 0.11 |
| Untreated | 5.17 ± 0.40b |
| 8t (1 μM) | 3.90 ± 0.30d |
| 8t (5 μM) | 4.10 ± 0.02d |
| INH (1 μM) | 2.25 ± 0.15c,d |
SD, standard deviation.
P < 0.0001 compared to early control group.
P < 0.002 compared to early control group.
P < 0.0001 compared to untreated group which was dosed with 0.5% DMSO. Multiple comparisons were performed with Tukey’s test. INH, isoniazid.