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. 2024 Dec 4;67(24):21781–21794. doi: 10.1021/acs.jmedchem.4c01302

Table 5. Intracellular Activity of 4-Alkoxyquinoline 8t in Murine Macrophages Model of TB Infectiona.

Entry Log10 CFU/well (Mean ± SD)
Early Control 3.28 ± 0.11
Untreated 5.17 ± 0.40b
8t (1 μM) 3.90 ± 0.30d
8t (5 μM) 4.10 ± 0.02d
INH (1 μM) 2.25 ± 0.15c,d
a

SD, standard deviation.

b

P < 0.0001 compared to early control group.

c

P < 0.002 compared to early control group.

d

P < 0.0001 compared to untreated group which was dosed with 0.5% DMSO. Multiple comparisons were performed with Tukey’s test. INH, isoniazid.