Table 1.
Effect of L-carnitine (LCAR, 300 and 500 mg/kg/day, IP) on general characteristics and serum hepatic function parameters in dexamethasone (DEXA)-toxified rats
| Control | DEXA | DEXA-MET | LCAR500 | DEXA-LCAR300 | DEXA-LCAR500 | |
|---|---|---|---|---|---|---|
| BW change (g) | 3.50 ± 3.62 | -82.00 ± 7.72* | -99.40 ± 10.71*# | 4.83 ± 3.66 | -77.67 ± 6.62*$ | -83.00 ± 7.04*$ |
| Liver index (%) | 3.38 ± 0.04 | 6.22 ± 0.51* | 4.68 ± 0.28*# | 3.04 ± 0.14 | 5.40 ± 0.48*#$ | 5.35 ± 0.59*# |
| ALT (U/L) | 55.00 ± 11.47 | 304.50 ± 91.90* | 226.10 ± 19.63* | 43.83 ± 12.54 | 222.00 ± 78.45* | 152.30 ± 42.73*# |
| AST (U/L) | 207.60 ± 20.66 | 379.30 ± 42.76* | 325.40 ± 75.76* | 157.70 ± 35.94 | 302.30 ± 69.95* | 282.00 ± 44.20# |
| GGT (U/L) | 18.83 ± 5.15 | 71.80 ± 12.25* | 29.63 ± 6.28 # | 16.22 ± 3.66 | 35.00 ± 11.05# | 34.33 ± 13.41# |
| ALP (U/L) | 547.30 ± 95.72 | 3381 ± 1062* | 852.20 ± 214.2# | 599.30 ± 165.50 | 1103 ± 251.4# | 416.00 ± 49.82# |
| LDH (U/L) | 1742 ± 517.40 | 5480 ± 1199* | 3529 ± 1139*# | 1623 ± 115 | 5331 ± 645.50*$ | 3477 ± 745.90*#! |
| Albumin (g/dL) | 4.55 ± 0.22 | 3.21 ± 0.35 * | 4.24 ± 0.47# | 4.68 ± 0.21 | 4.19 ± 0.26# | 4.33 ± 0.25# |
| Total bilirubin (mg/dL) | 0.35 ± 0.05 | 0.96 ± 0.16* | 0.37 ± 0.12# | 0.19 ± 0.02 | 0.31 ± 0.15# | 0.32 ± 0.08# |
Data are shown as means ± SD, n = 6 per group
BW, body weight; AST, aspartate aminotransferase; ALT, alanine aminotransferase; GGT, gamma-glutamyl transferase; ALP, alkaline phosphatase; LDH, lactate dehydrogenase
*,#,$,!P < 0.05 versus control, DEXA, DEXA-MET, and DEXA-LCAR300 groups, respectively