Table 3.
Recent studies on L1CAM of endometrial cancer
| Title (Year) | Author | Objective | Major Finding |
|---|---|---|---|
| The role of L1CAM as predictor of poor prognosis in stage I endometrial cancer: a systematic review and meta-analysis (2023) | Giannini, A. et al | To evaluate the prognostic significance of L1CAM expression in patients with stage I endometrial cancer | High L1CAM expression was associated with worse DFS and OS. Additionally, high L1CAM levels correlated with more aggressive FIGO grade and older age |
| Enhanced Risk Stratification in Early-Stage Endometrial Cancer: Integrating POLE through Droplet Digital PCR and L1CAM (2023) | Joe, S. et al | To enhance risk stratification in early-stage endometrial cancer by integrating POLE mutations via ddPCR and L1CAM expression | L1CAM overexpression, especially in the NSMP subgroup, was significantly associated with poorer prognosis. POLE ddPCR identified mutations cost-effectively, showing potential as an alternative to NGS |
| Prognostic significance of L1CAM expression in addition to ProMisE in endometrial cancer (2023) | Kim, J. et al | To evaluate the prognostic value of L1CAM expression in conjunction with the ProMisE molecular classification for endometrial cancer | L1CAM was identified as an independent poor prognostic factor for PFS, especially in p53 wild-type cases, whereas β-catenin and PD-L1 were not associated with recurrence |
| Evaluation of prognostic potential of β-catenin and L1CAM expression according to endometrial cancer risk group (2024) | Yoon, H. et al | To assess the prognostic roles of β-catenin and L1CAM expressions in endometrial cancer risk groups | β-catenin was associated with poor PFS in high-intermediate-risk patients, while L1CAM was linked with advanced pathological features but was not an independent prognostic factor |
| Prognostic Significance of L1 Cell Adhesion Molecule in NSMP Endometrial Cancer (2024) | Ozdemir, C.Y. et al | To investigate the role of L1CAM expression in endometrial cancers classified as having NSMP for improving prognostic stratification | L1CAM positivity was significantly associated with worse outcomes, including higher recurrence rates, lymphovascular invasion, and lower progression-free and overall survival, especially within the NSMP group |
L1CAM L1 Cell Adhesion Molecule, DFS disease-free survival, OS overall survival, ddPCR droplet digital PCR, IHC immunohistochemistry, NGS Next Generation Sequencing, PFS progression-free survival, dMMR Mismatch repair-deficient, p53abn p53 abnormal, NSMP no specific molecular profile