Table 3.

Multivariate Cox models for long-term mortality for the hs-CRP/HDL-C ratio in the pooled cohort

	Model 1 HR (95% CI)	P value	Model 2 HR (95% CI)	P value	Model 3 HR (95% CI)	P value
All-cause mortality
HDL-C (mg/L)	0.98 (0.90, 1.05)	0.528	0.94 (0.86, 1.03)	0.208	0.98 (0.90, 1.08)	0.737
Hs-CRP (mg/L)	1.02 (1.01, 1.03)	< 0.001	1.02 (1.01, 1.03)	< 0.001	1.02 (1.01, 1.03)	< 0.001
Hs-CRP/HDL-C ratio	1.10 (1.07, 1.13)	< 0.001	1.10 (1.07, 1.14)	< 0.001	1.09 (1.05, 1.13)	< 0.001
Cardiovascular mortality
HDL-C (mg/L)	0.75 (0.62, 0.91)	0.003	0.74 (0.60, 0.91)	0.005	0.82 (0.66, 1.02)	0.071
Hs-CRP (mg/L)	1.02 (1.00, 1.03)	0.013	1.02 (1.01, 1.04)	0.002	1.02 (1.00, 1.04)	0.014
Hs-CRP/HDL-C ratio	1.10 (1.05, 1.16)	< 0.001	1.14 (1.08, 1.21)	< 0.001	1.11 (1.05, 1.19)	0.001

HR, hazard ratio; CI, confidence interval

Model 1: non-adjusted

Model 2: adjusted for age, sex, race, drinking, smoking and BMI

Model 3: adjusted for age, sex, race, drinking, smoking, BMI, hypertension, diabetes, heart failure, coronary artery disease, stroke and lipid-lowering drugs