Table 2.

Statistical outputs of the multiple linear regression models investigating the main effects of plasma Alzheimer’s disease-related biomarkers (predictors) on outcome measures of actigraphy-derived 24-h rest-activity rhythm fragmentation (intradaily variability, top) or stability (interdaily stability, bottom) in the whole study sample (n = 92). Abbreviations: Aβ_42/40 = amyloid-beta_42/40 ratio, AD = Alzheimer’s disease, GFAP = glial fibrillary acidic protein, NfL = neurofilament light chain, t-tau = total tau, p-tau₁₈₁ = tau phosphorylated at threonine 181, p-tau₂₃₁ = tau phosphorylated at threonine 231

	Intradaily variability
	NfL		GFAP		Aβ42/40		t-tau		p-tau181		p-tau231
	t	P	t	P	t	P	t	P	t	P	t	P
Plasma AD biomarker	4.26	< 0.0001	2.49	0.01	-1.95	0.054	0.98	0.33	-0.54	0.59	0.46	0.65
Age	-1.21	0.23	0.43	0.67	1.18	0.24	1.24	0.22	1.23	0.22	1.44	0.15
Male sex	2.69	0.009	2.84	0.006	2.59	0.01	2.30	0.02	2.24	0.03	2.29	0.02
Education	0.85	0.40	1.01	0.32	0.80	0.43	0.89	0.38	0.80	0.42	0.97	0.34
Body mass index	0.86	0.39	0.59	0.57	0.06	0.96	0.61	0.55	0.54	0.59	0.77	0.45
Actigraphic recording duration	1.61	0.11	1.86	0.07	1.67	0.10	2.65	0.01	2.83	0.006	1.94	0.06
	Interdaily stability
	NfL		GFAP		Aβ 42/40		t-tau		p-tau 181		p-tau 231
	t	P	t	P	t	P	t	P	t	P	t	P
Plasma AD biomarker	-2.24	0.03	-0.60	0.55	-0.12	0.91	-0.23	0.82	-0.54	0.59	-0.73	0.47
Age	4.20	< 0.001	5.36	< 0.001	3.30	0.001	3.18	0.002	3.26	0.002	3.29	0.001
Male sex	-1.80	0.08	-1.86	0.07	-1.81	0.07	-1.74	0.09	-1.57	0.12	-1.82	0.07
Education	-1.95	0.06	-1.94	0.06	-1.90	0.06	-2.03	0.05	-2.01	0.05	-2.11	0.04
Body mass index	-1.34	0.18	-1.00	0.32	-0.88	0.38	-1.15	0.25	-1.23	0.22	-1.12	0.27
Actigraphic recording duration	-1.74	0.09	-1.84	0.07	-0.12	0.91	-1.82	0.07	-1.76	0.08	-1.66	0.10