Table 3.

Statistical outputs of the multiple linear regression models testing for sex differences (interaction effects) in the relationships between plasma Alzheimer’s disease-related biomarkers (predictors) and outcomes measures of actigraphy-derived 24-h rest-activity fragmentation (intradaily variability, top) or stability (interdaily stability, bottom). Abbreviations: Aβ_42/40 = amyloid-beta_42/40 ratio, AD = Alzheimer’s disease, GFAP = glial fibrillary acidic protein, NfL = neurofilament light chain, t-tau = total tau, p-tau₁₈₁ = tau phosphorylated at threonine 181, p-tau₂₃₁ = tau phosphorylated at threonine 231

	Intradaily variability
	NfL		GFAP		Aβ42/40		t-tau		p-tau181		p-tau231
	t	P	t	P	t	P	t	P	t	P	t	P
Plasma AD biomarker*Male sex	4.05	< 0.001	3.60	< 0.001	-1.01	0.32	0.36	0.72	3.71	< 0.001	3.28	0.002
Plasma AD biomarker	1.26	0.21	-0.16	0.87	-0.60	0.55	0.54	0.59	-2.78	0.007	-1.76	0.08
Age	-1.75	0.09	0.30	0.77	1.11	0.27	1.26	0.21	1.82	0.07	1.78	0.08
Male sex	-2.65	0.01	-2.17	0.03	1.37	0.17	0.28	0.78	-2.74	0.008	-2.37	0.02
Education	0.87	0.39	0.86	0.39	0.88	0.38	0.92	0.36	0.95	0.35	1.03	0.31
Body mass index	1.02	0.31	0.77	0.44	0.27	0.79	0.58	0.56	0.39	0.70	0.87	0.39
Actigraphic recording duration	1.46	0.15	2.29	0.02	1.65	0.10	2.59	0.01	2.00	0.05	-1.44	0.15
	Interdaily stability
	NfL		GFAP		Aβ 42/40		t-tau		p-tau 181		p-tau 231
	t	P	t	P	t	P	t	P	t	P	t	P
Plasma AD biomarker*Male sex	-1.73	0.09	-1.47	0.15	-0.01	0.99	0.94	0.35	-3.30	0.001	-1.67	0.09
Plasma AD biomarker	-0.77	0.45	0.44	0.66	-0.08	0.94	-0.77	0.45	1.62	0.11	0.52	0.61
Age	4.41	< 0.001	3.44	< 0.001	3.27	0.002	3.25	0.002	2.98	0.004	3.18	0.002
Male sex	0.92	0.36	0.64	0.52	-0.26	0.80	-1.38	0.17	2.59	0.01	1.02	0.31
Education	-1.95	0.06	-1.87	0.07	-1.88	0.06	-1.93	0.06	-2.21	0.03	-2.13	0.04
Body mass index	-1.39	0.17	-1.07	0.29	-0.86	0.39	-1.21	0.23	-1.13	0.26	-1.16	0.25
Actigraphic recording duration	-1.63	0.11	-1.97	0.05	-1.80	0.08	-1.89	0.06	-0.96	0.34	-1.36	0.18