Table 2.
The top 20 genes from gene-based analysis by using VEGAS2 tool
| Chr | Gene | Number of SNPs |
Start position | Stop position | P-value | Top-SNP | Top-SNP P-value |
|---|---|---|---|---|---|---|---|
| FEV1 | |||||||
| 12 | TESC | 185 | 117,476,727 | 117,537,251 | 6.40E-05 | rs7304889 | 3.75E-05 |
| 12 | KRT5 | 28 | 52,908,358 | 52,914,243 | 1.35E-04 | rs60314569 | 4.96E-05 |
| 17 | ARHGDIA | 5 | 79,825,596 | 79,829,282 | 1.57E-04 | rs113301975 | 1.49E-04 |
| 23 | MBNL3 | 43 | 131,503,342 | 131,623,996 | 1.71E-04 | rs1952453 | 1.38E-04 |
| 6 | GPR126 | 172 | 142,623,055 | 142,767,403 | 1.75E-04 | rs2039986 | 1.60E-05 |
| 23 | RAP2C | 5 | 131,337,051 | 131,353,508 | 1.95E-04 | rs5977658 | 2.00E-04 |
| 23 | RAP2C-AS1 | 116 | 131,352,534 | 131,566,839 | 2.05E-04 | rs1952453 | 1.38E-04 |
| 17 | TBC1D16 | 279 | 77,906,141 | 78,009,657 | 2.23E-04 | rs11653700 | 2.39E-06 |
| 17 | FAM195B | 18 | 79,780,236 | 79,791,170 | 3.41E-04 | rs140438341 | 1.96E-04 |
| 6 | FHL5 | 103 | 97,010,423 | 97,064,512 | 3.50E-04 | rs12204342 | 2.56E-05 |
| 7 | ADCYAP1R1 | 133 | 31,092,075 | 31,151,093 | 4.12E-04 | rs4723047 | 8.25E-08 |
| 17 | PPP1R27 | 2 | 79,791,367 | 79,792,926 | 4.25E-04 | rs34856581 | 3.43E-04 |
| 7 | SEPT7P2 | 79 | 45,763,385 | 45,808,617 | 4.54E-04 | rs1004028 | 3.60E-04 |
| 10 | FAM196A | 106 | 128,933,689 | 128,994,422 | 5.58E-04 | rs2486971 | 9.90E-05 |
| 17 | P4HB | 34 | 79,801,033 | 79,818,544 | 5.91E-04 | rs111839893 | 2.94E-04 |
| 23 | FRMD7 | 32 | 131,211,020 | 131,262,050 | 7.96E-04 | rs5933079 | 5.97E-05 |
| 12 | C12orf80 | 5 | 52,599,364 | 52,604,639 | 8.36E-04 | rs4144987 | 3.06E-03 |
| 23 | TAF7L | 39 | 100,523,240 | 100,548,059 | 9.90E-04 | rs5991927 | 3.01E-04 |
| 12 | IRAK4 | 53 | 44,152,746 | 44,183,346 | 1.02E-03 | rs4251463 | 3.90E-04 |
| 11 | LOC440040 | 506 | 49,580,079 | 49,831,969 | 1.02E-03 | rs11040429 | 1.72E-04 |
| FVC | |||||||
| 6 | GPR126 | 172 | 142,623,055 | 142,767,403 | 1.50E-05 | rs9403380 | 1.27E-07 |
| 6 | FKBP5 | 225 | 35,541,361 | 35,696,360 | 1.80E-05 | rs12153967 | 4.39E-06 |
| 13 | SLC15A1 | 173 | 99,336,054 | 99,404,929 | 2.40E-05 | rs1768042 | 2.97E-04 |
| 18 | AQP4 | 17 | 24,432,007 | 24,445,716 | 2.60E-05 | rs455671 | 5.10E-05 |
| 9 | SETX | 324 | 135,136,826 | 135,230,372 | 1.78E-04 | rs508021 | 1.22E-04 |
| 12 | C12orf80 | 5 | 52,599,364 | 52,604,639 | 2.67E-04 | rs1317997 | 9.70E-04 |
| 12 | IRAK4 | 53 | 44,152,746 | 44,183,346 | 3.45E-04 | rs4251463 | 1.55E-04 |
| 11 | LOC646813 | 36 | 50,368,317 | 50,379,802 | 3.57E-04 | rs692671 | 2.69E-04 |
| 11 | LOC440040 | 506 | 49,580,079 | 49,831,969 | 3.62E-04 | rs10742953 | 9.12E-05 |
| 19 | CABP5 | 83 | 48,532,639 | 48,547,311 | 3.82E-04 | rs111784716 | 2.17E-04 |
| 23 | RAP2C | 5 | 131,337,051 | 131,353,508 | 3.85E-04 | rs5977658 | 3.52E-04 |
| 7 | ADCYAP1R1 | 133 | 31,092,075 | 31,151,093 | 3.91E-04 | rs4503014 | 1.48E-07 |
| 23 | RAP2C-AS1 | 116 | 131,352,534 | 131,566,839 | 4.08E-04 | rs142507995 | 3.36E-04 |
| 7 | DNAJB6 | 283 | 157,129,709 | 157,210,133 | 4.26E-04 | rs12154512 | 3.07E-04 |
| 16 | CALB2 | 88 | 71,392,615 | 71,424,342 | 4.86E-04 | rs11545954 | 1.40E-05 |
| 23 | MBNL3 | 43 | 131,503,342 | 131,623,996 | 6.17E-04 | rs5977691 | 3.36E-04 |
| 10 | FGF8 | 2 | 103,529,886 | 103,540,126 | 6.74E-04 | rs1348870 | 1.57E-04 |
| 23 | FRMD7 | 32 | 131,211,020 | 131,262,050 | 6.84E-04 | rs5933079 | 1.03E-04 |
| 12 | MKRN9P | 5 | 88,176,662 | 88,178,488 | 7.17E-04 | rs1675574 | 4.63E-04 |
| 19 | SLC5A5 | 32 | 17,982,781 | 18,005,983 | 7.43E-04 | rs7255433 | 7.70E-05 |
| FEV1/FVC | |||||||
| 5 | RPL37 | 9 | 40,831,429 | 40,835,387 | 2.43E-04 | rs2291782 | 8.52E-04 |
| 2 | LOC101928113 | 6 | 86,116,402 | 86,119,375 | 3.86E-04 | rs4313976 | 1.21E-04 |
| 2 | LOC728730 | 234 | 39,664,556 | 39,828,484 | 6.32E-04 | rs10210842 | 3.22E-05 |
| 1 | KLHL17 | 25 | 895,966 | 901,099 | 7.10E-04 | rs41285808 | 6.56E-05 |
| 1 | CD1B | 4 | 158,297,739 | 158,301,321 | 1.36E-03 | rs962879 | 8.61E-04 |
| 2 | C2orf81 | 4 | 74,641,302 | 74,644,844 | 1.42E-03 | rs7571984 | 9.31E-04 |
| 3 | GSK3B | 263 | 119,540,801 | 119,813,264 | 1.52E-03 | rs60235167 | 1.30E-04 |
| 3 | BTD | 77 | 15,642,858 | 15,687,328 | 1.59E-03 | rs2455822 | 2.22E-04 |
| 1 | C8A | 153 | 57,320,442 | 57,383,894 | 1.77E-03 | rs2284952 | 1.16E-03 |
| 2 | GAL3ST2 | 62 | 242,716,239 | 242,743,702 | 2.01E-03 | rs74704923 | 5.61E-04 |
| 3 | BPESC1 | 39 | 138,823,026 | 138,844,005 | 2.05E-03 | rs586043 | 1.38E-03 |
| 2 | MDH1 | 6 | 63,815,742 | 63,834,330 | 2.09E-03 | rs17618390 | 6.18E-04 |
| 4 | CCDC110 | 76 | 186,366,337 | 186,392,913 | 2.19E-03 | rs57923780 | 5.62E-06 |
| 5 | GCNT4 | 7 | 74,323,288 | 74,326,724 | 2.25E-03 | rs3811986 | 1.78E-03 |
| 3 | LINC00606 | 11 | 10,801,168 | 10,805,877 | 2.41E-03 | rs35131573 | 6.57E-04 |
| 3 | RAD18 | 281 | 8,918,879 | 9,005,159 | 2.67E-03 | rs579898 | 8.73E-04 |
| 3 | Section 62 | 56 | 169,684,579 | 169,716,161 | 2.89E-03 | rs3348 | 3.65E-04 |
| 1 | HNRNPU | 2 | 245,013,601 | 245,027,827 | 2.93E-03 | rs3766527 | 7.68E-03 |
| 3 | RNF168 | 48 | 196,195,656 | 196,230,639 | 3.20E-03 | rs9869437 | 7.07E-04 |
| 3 | DCBLD2 | 227 | 98,514,813 | 98,620,533 | 3.29E-03 | rs2439237 | 7.02E-04 |
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