Table 4.
The SNPs with nominal significance (P < 0.05) in UK Biobank validation analysis
| Discovery | Validation | ||||||
|---|---|---|---|---|---|---|---|
| SNP | Chr | BP | P value | P value | Enhancers | Gene* | |
| FEV1 | |||||||
| rs35031103 | 3 | 176,086,799 | 1.28E-07 | 3.09E-02 | - | ||
| rs34981006 | 3 | 176,087,566 | 2.58E-07 | 2.14E-02 | |||
| rs7632772 | 3 | 176,103,902 | 4.25E-07 | 2.30E-02 | |||
| rs34817694 | 3 | 176,118,748 | 4.38E-07 | 2.35E-02 | enh113420 | ||
| rs66475255 | 3 | 176,107,428 | 5.02E-07 | 2.10E-02 | |||
| rs13084577 | 3 | 176,113,219 | 8.33E-07 | 4.76E-02 | |||
| rs186195940 | 4 | 138,380,119 | 1.29E-06 | 1.29E-02 | |||
| rs192813943 | 4 | 138,326,821 | 2.34E-06 | 2.86E-02 | |||
| rs149612364 | 22 | 48,967,243 | 3.71E-06 | 1.45E-02 | TAFA5 | ||
| rs10871500 | 17 | 77,980,564 | 4.08E-06 | 2.14E-02 | TBC1D16 | enh17427 |
TBC1D16, CCDC40, GAA |
| rs8070465 | 17 | 77,978,990 | 9.36E-06 | 2.47E-02 | TBC1D16 | enh17427 |
TBC1D16, CCDC40, GAA |
| rs507108 | 6 | 151,327,692 | 5.75E-06 | 4.65E-02 | MTHFD1L | enh9447 | |
| FVC | |||||||
| rs35031103 | 3 | 176,086,799 | 2.42E-06 | 3.23E-02 | |||
| rs34981006 | 3 | 176,087,566 | 4.73E-06 | 2.51E-02 | |||
| rs34817694 | 3 | 176,118,748 | 4.87E-06 | 2.08E-02 | |||
| rs7632772 | 3 | 176,103,902 | 7.40E-06 | 2.80E-02 | |||
| rs66475255 | 3 | 176,107,428 | 8.70E-06 | 2.77E-02 | |||
| rs186195940 | 4 | 138,380,119 | 9.26E-06 | 9.35E-03 |
*: Genes possibly regulated by Enhancers