Table 2.

Quality assessment of two included randomized controlled clinical trials

No. of studies	Certainty assessment							No. of patients		Effect	Certainty
	Study design	Efficacy outcome	Risk of bias	Inconsistency	Indirectness	Imprecision	Other considerations	Omava	PBOb	Relative (95% CI)
1	Randomized trial	Peak work attained during maximal exercise testing	Low	Low	Low	Low	None	52	17	1.1, 21.9	⊕⊕⊕⊕ High
2	Randomized trial	mFARSc score	Low	Low	Low	Low	None	51	52	− 2.93 to − 0.18	⊕⊕⊕⊕ High

^aOmaveloxolone treated

^bPlacebo

^cmodified Friedreich’s Ataxia Rating Scale