Table 1.
miRNA-mRNA interactions observed in HepG2 and SNU449 cells treated with Sorafenib for 6 and 24 hours
|
Condition
|
hsa-miR
|
log2 (Fold-change)
|
P value
|
P-adj
|
mRNA target
|
Transcript ID
|
log2 (Fold-change)
|
P-adj
|
| HepG2 6 hours | hsa-miR-29b-3p | -1.374 | 3.23E-02 | 0.9961 | HRK | ENSG00000135116.9 | 1.967 | 8.926E-08 |
| HepG2 6 hours | hsa-miR-29b-3p | -1.374 | 3.23E-02 | 0.9961 | JMY | ENSG00000152409.9 | 1.105 | 2.253E-13 |
| HepG2 6 hours | hsa-miR-29b-3p | -1.374 | 3.23E-02 | 0.9961 | TNFAIP3 | ENSG00000118503.15 | 1.186 | 4.131E-07 |
| HepG2 6 hours | hsa-miR-19b-3p | -1.277 | 4.29E-02 | 0.9961 | RORA | ENSG00000069667.16 | 1.048 | 1.506E-03 |
| HepG2 6 hours | hsa-miR-19b-3p | -1.277 | 4.29E-02 | 0.9961 | TNFAIP3 | ENSG00000118503.15 | 1.186 | 4.131E-07 |
| HepG2 6 hours | hsa-miR-19b-3p | -1.277 | 4.29E-02 | 0.9961 | ZNF385B | ENSG00000144331.20 | 1.159 | 1.233E-02 |
| HepG2 6 hours | hsa-miR-19b-3p | -1.277 | 4.29E-02 | 0.9961 | ARRDC3 | ENSG00000113369.9 | 1.697 | 4.636E-30 |
| HepG2 24 hours | hsa-miR-4521 | -4.496 | 1.09E-04 | 0.1484 | MBNL1 | ENSG00000152601.17 | 1.242 | 2.599E-16 |
| HepG2 24 hours | hsa-miR-7974 | -3.432 | 1.97E-42 | 0.0000 | CREB3 L3 | ENSG00000060566.14 | 1.062 | 4.001E-06 |
| HepG2 24 hours | hsa-miR-194-3p | -1.463 | 2.73E-08 | 0.0000 | ARHGAP24 | ENSG00000138639.18 | 1.281 | 1.186E-08 |
| HepG2 24 hours | hsa-miR-194-3p | -1.463 | 4.47E-05 | 0.0020 | HOXA1 | ENSG00000105991.9 | 1.192 | 2.484E-06 |
| HepG2 24 hours | hsa-miR-374a-3p | -1.327 | 4.47E-05 | 0.0020 | SH3GLB1 | ENSG00000097033.14 | 1.296 | 1.800E-13 |
| HepG2 24 hours | hsa-miR-374a-3p | -1.327 | 8.95E-03 | 0.1859 | OXR1 | ENSG00000164830.18 | 1.050 | 2.089E-08 |
| HepG2 24 hours | hsa-miR-374a-3p | -1.327 | 8.95E-03 | 0.1859 | GOLGA4 | ENSG00000144674.16 | 1.230 | 8.419E-03 |
| HepG2 24 hours | hsa-miR-374a-3p | -1.327 | 8.95E-03 | 0.1859 | ARRDC3 | ENSG00000113369.9 | 2.849 | 2.203E-41 |
| HepG2 24 hours | hsa-miR-27b-5p | -1.236 | 8.95E-03 | 0.1859 | OPTN | ENSG00000123240.17 | 1.531 | 6.346E-20 |
| HepG2 24 hours | hsa-miR-193b-3p | -1.193 | 3.74E-04 | 0.0143 | SIAH1 | ENSG00000196470.12 | 1.581 | 1.144E-38 |
| HepG2 24 hours | hsa-miR-193b-3p | -1.193 | 2.29E-02 | 0.3864 | LAMC2 | ENSG00000058085.15 | 1.327 | 2.152E-03 |
| HepG2 24 hours | hsa-miR-3187-3p | -1.169 | 2.29E-02 | 0.3864 | PLK2 | ENSG00000145632.15 | 1.634 | 3.009E-08 |
| HepG2 24 hours | hsa-miR-3187-3p | -1.169 | 3.59E-02 | 0.4538 | ATOH8 | ENSG00000168874.13 | 1.691 | 6.502E-08 |
| HepG2 24 hours | hsa-miR-374b-3p | -1.064 | 3.59E-02 | 0.4538 | SMAD7 | ENSG00000101665.9 | 1.999 | 1.669E-42 |
| HepG2 24 hours | hsa-miR-374b-3p | -1.064 | 7.47E-03 | 0.1693 | TIRARP | ENSG00000163659.13 | 1.070 | 1.555E-18 |
| HepG2 24 hours | hsa-miR-769-5p | -1.058 | 7.47E-03 | 0.1693 | TFAP4 | ENSG00000090447.12 | 1.010 | 1.161E-11 |
| HepG2 24 hours | hsa-miR-769-5p | -1.058 | 8.79E-03 | 0.1859 | FAXDC2 | ENSG00000170271.11 | 1.565 | 1.249E-13 |
| HepG2 24 hours | hsa-miR-4488 | 9.059 | 8.79E-03 | 0.1859 | MELTF | ENSG00000163975.12 | -1.085 | 2.722E-05 |
| SNU 6 hours | hsa-miR-15a-5p | -1.526 | 9.20E-03 | 0.6536 | CHAC1 | ENSG00000128965.13 | 2.262 | 5.787E-28 |
| SNU 6 hours | hsa-miR-12135 | -1.298 | 2.11E-02 | 0.6536 | FOXJ1 | ENSG00000129654.8 | 1.240 | 2.099E-06 |
| SNU 24 hours | hsa-miR-29b-1-5p | -2.126 | 2.50E-05 | 0.0007 | HEY1 | ENSG00000164683.17 | 1.692 | 2.304E-07 |
| SNU 24 hours | hsa-miR-374c-5p | -1.884 | 5.25E-03 | 0.0787 | CEBPB | ENSG00000172216.6 | 1.002 | 5.306E-17 |
| SNU 24 hours | hsa-miR-374c-5p | -1.884 | 5.25E-03 | 0.0787 | VEGFA | ENSG00000112715.22 | 1.448 | 2.131E-45 |
| SNU 24 hours | hsa-miR-374c-5p | -1.884 | 5.25E-03 | 0.0787 | ADM | ENSG00000148926.10 | 2.340 | 1.782E-143 |
| SNU 24 hours | hsa-miR-32-3p | -1.821 | 9.41E-04 | 0.0175 | YOD1 | ENSG00000180667.10 | 1.658 | 1.063E-111 |
| SNU 24 hours | hsa-miR-32-3p | -1.821 | 9.41E-04 | 0.0175 | TNFAIP3 | ENSG00000118503.15 | 2.316 | 3.471E-10 |
| SNU 24 hours | hsa-let-7b-3p | -1.541 | 1.72E-02 | 0.1785 | KLF4 | ENSG00000136826.15 | 1.572 | 1.166E-31 |
| SNU 24 hours | hsa-let-7b-3p | -1.541 | 1.72E-02 | 0.1785 | ADRB2 | ENSG00000169252.5 | 1.743 | 9.094E-48 |
| SNU 24 hours | hsa-miR-195-5p | -1.456 | 1.51E-02 | 0.1770 | VEGFA | ENSG00000112715.22 | 1.448 | 2.131E-45 |
| SNU 24 hours | hsa-miR-195-5p | -1.456 | 1.51E-02 | 0.1770 | ADRB2 | ENSG00000169252.5 | 1.743 | 9.094E-48 |
| SNU 24 hours | hsa-miR-34a-5p | -1.316 | 2.62E-02 | 0.2364 | KLF4 | ENSG00000136826.15 | 1.572 | 1.166E-31 |
| SNU 24 hours | hsa-miR-34a-5p | -1.316 | 2.62E-02 | 0.2364 | HSPA1B | ENSG00000204388.7 | 1.676 | 2.822E-82 |
| SNU 24 hours | hsa-miR-5701 | 1.535 | 3.44E-02 | 0.2740 | SYNGR3 | ENSG00000127561.15 | -1.505 | 1.627E-08 |
| SNU 24 hours | hsa-miR-5701 | 1.535 | 3.44E-02 | 0.2740 | RFLNB | ENSG00000183688.4 | -1.340 | 1.864E-27 |
| SNU 24 hours | hsa-miR-12136 | 3.334 | 4.93E-16 | 0.0000 | ACVR2B | ENSG00000114739.14 | -1.075 | 3.211E-13 |
| SNU 24 hours | hsa-miR-12136 | 3.334 | 4.93E-16 | 0.0000 | NR4A2 | ENSG00000153234.14 | -1.754 | 9.174E-06 |
| SNU 24 hours | hsa-miR-12136 | 3.334 | 4.93E-16 | 0.0000 | CSPG5 | ENSG00000114646.10 | -1.089 | 1.709E-08 |
| SNU 24 hours | hsa-miR-12136 | 3.334 | 4.93E-16 | 0.0000 | AREG | ENSG00000109321.11 | -1.016 | 2.623E-03 |
| SNU 24 hours | hsa-miR-12136 | 3.334 | 4.93E-16 | 0.0000 | NRARP | ENSG00000198435.4 | -1.763 | 3.743E-12 |
| SNU 24 hours | hsa-miR-12136 | 3.334 | 4.93E-16 | 0.0000 | MAF | ENSG00000178573.7 | -1.748 | 5.311E-04 |
| SNU 24 hours | hsa-miR-4492 | 8.427 | 4.75E-12 | 0.0000 | IGFBP5 | ENSG00000115461.5 | -1.073 | 2.379E-18 |
| SNU 24 hours | hsa-miR-4488 | 13.091 | 1.08E-32 | 0.0000 | PDGFB | ENSG00000100311.17 | -1.101 | 1.086E-51 |