Table 2.
Predicted interactions between miRNAs and mRNAs, and between their corresponding lncRNAs in HepG2 and SNU449 cells treated with Sorafenib for 6 and 24 hours
|
Condition
|
miRNA
|
log2 (Fold-change)
|
Target
|
Target type
|
Transcript ID
|
log2 (Fold-change)
|
P-adj
|
| HepG2 6 hours | hsa-miR-19b-3p | -1.277 | RORA | mRNA | ENSG00000069667.16 | 1.048 | 1.51E-03 |
| HepG2 6 hours | hsa-miR-19b-3p | -1.277 | TNFAIP3 | mRNA | ENSG00000118503.15 | 1.186 | 4.13E-07 |
| HepG2 6 hours | hsa-miR-19b-3p | -1.277 | ZNF385B | mRNA | ENSG00000144331.20 | 1.159 | 1.23E-02 |
| HepG2 6 hours | hsa-miR-29b-3p | -1.374 | HRK | mRNA | ENSG00000135116.9 | 1.967 | 8.93E-08 |
| HepG2 6 hours | hsa-miR-29b-3p | -1.374 | JMY | mRNA | ENSG00000152409.9 | 1.105 | 2.25E-13 |
| HepG2 6 hours | hsa-miR-29b-3p | -1.374 | TNFAIP3 | mRNA | ENSG00000118503.15 | 1.186 | 4.13E-07 |
| HepG2 24 hours | hsa-miR-193b-3p | -1.193 | CYTOR | lncRNA | ENSG00000222041.11 | 1.421 | 7.45E-21 |
| HepG2 24 hours | hsa-miR-193b-3p | -1.193 | MIR4435-2HG | lncRNA | ENSG00000172965.16 | 1.204 | 7.19E-10 |
| HepG2 24 hours | hsa-miR-193b-3p | -1.193 | PCBP2-OT1 | lncRNA | ENSG00000282977.1 | 1.086 | 8.35E-03 |
| HepG2 24 hours | hsa-miR-193b-3p | -1.193 | ZFAS1 | lncRNA | ENSG00000177410.13 | 1.413 | 4.96E-35 |
| HepG2 24 hours | hsa-miR-193b-3p | -1.193 | SIAH1 | mRNA | ENSG00000196470.12 | 1.581 | 1.14E-38 |
| HepG2 24 hours | hsa-miR-193b-3p | -1.193 | LAMC2 | mRNA | ENSG00000058085.15 | 1.327 | 2.15E-03 |
| HepG2 24 hours | hsa-miR-3187-3p | -1.169 | MIR4435-2HG | lncRNA | ENSG00000172965.16 | 1.204 | 7.19E-10 |
| HepG2 24 hours | hsa-miR-3187-3p | -1.169 | DANT2 | lncRNA | ENSG00000235244.4 | 1.014 | 1.37E-02 |
| HepG2 24 hours | hsa-miR-3187-3p | -1.169 | PLK2 | mRNA | ENSG00000145632.15 | 1.634 | 3.01E-08 |
| HepG2 24 hours | hsa-miR-3187-3p | -1.169 | ATOH8 | mRNA | ENSG00000168874.13 | 1.691 | 6.50E-08 |
| HepG2 24 hours | hsa-miR-374a-3p | -1.327 | MIR4435-2HG | lncRNA | ENSG00000172965.16 | 1.204 | 7.19E-10 |
| HepG2 24 hours | hsa-miR-374a-3p | -1.327 | OXR1 | mRNA | ENSG00000164830.18 | 1.050 | 2.09E-08 |
| HepG2 24 hours | hsa-miR-374a-3p | -1.327 | GOLGA4 | mRNA | ENSG00000144674.16 | 1.230 | 8.42E-03 |
| HepG2 24 hours | hsa-miR-374a-3p | -1.327 | ARRDC3 | mRNA | ENSG00000113369.9 | 2.849 | 2.20E-41 |
| HepG2 24 hours | hsa-miR-374b-3p | -1.064 | THAP9-AS1 | lncRNA | ENSG00000251022.6 | 1.954 | 2.61E-55 |
| HepG2 24 hours | hsa-miR-374b-3p | -1.064 | MALAT1 | lncRNA | ENSG00000251562.8 | 1.024 | 2.38E-10 |
| HepG2 24 hours | hsa-miR-374b-3p | -1.064 | SMAD7 | mRNA | ENSG00000101665.9 | 1.999 | 1.67E-42 |
| HepG2 24 hours | hsa-miR-374b-3p | -1.064 | TIRARP | mRNA | ENSG00000163659.13 | 1.070 | 1.55E-18 |
| HepG2 24 hours | hsa-miR-769-5p | -1.058 | MALAT1 | lncRNA | ENSG00000251562.8 | 1.024 | 2.38E-10 |
| HepG2 24 hours | hsa-miR-769-5p | -1.058 | SNHG17 | lncRNA | ENSG00000196756.13 | 1.093 | 1.46E-10 |
| HepG2 24 hours | hsa-miR-769-5p | -1.058 | TFAP4 | mRNA | ENSG00000090447.12 | 1.010 | 1.16E-11 |
| HepG2 24 hours | hsa-miR-769-5p | -1.058 | FAXDC2 | mRNA | ENSG00000170271.11 | 1.565 | 1.25E-13 |
| HepG2 24 hours | hsa-miR-4521 | -4.496 | MBNL1 | mRNA | ENSG00000152601.17 | 1.242 | 2.60E-16 |
| HepG2 24 hours | hsa-miR-7974 | -3.432 | CREB3 L3 | mRNA | ENSG00000060566.14 | 1.062 | 4.00E-06 |
| HepG2 24 hours | hsa-miR-194-3p | -1.463 | ARHGAP24 | mRNA | ENSG00000138639.18 | 1.281 | 1.19E-08 |
| HepG2 24 hours | hsa-miR-194-3p | -1.463 | HOXA1 | mRNA | ENSG00000105991.9 | 1.192 | 2.48E-06 |
| HepG2 24 hours | hsa-miR-27b-5p | -1.236 | OPTN | mRNA | ENSG00000123240.17 | 1.531 | 6.35E-20 |
| HepG2 24 hours | hsa-miR-4488 | 9.059 | MELTF | mRNA | ENSG00000163975.12 | -1.085 | 2.72E-05 |
| SNU 6 hours | hsa-miR-15a-5p | -1.526 | CHAC1 | mRNA | ENSG00000128965.13 | 2.262 | 5.79E-28 |
| SNU 6 hours | hsa-miR-12135 | -1.298 | FOXJ1 | mRNA | ENSG00000129654.8 | 1.240 | 2.10E-06 |
| SNU 24 hours | hsa-miR-29b-1-5p | -2.126 | HEY1 | mRNA | ENSG00000164683.17 | 1.692 | 2.30E-07 |
| SNU 24 hours | hsa-miR-374c-5p | -1.884 | CEBPB | mRNA | ENSG00000172216.6 | 1.002 | 5.31E-17 |
| SNU 24 hours | hsa-miR-374c-5p | -1.884 | VEGFA | mRNA | ENSG00000112715.22 | 1.448 | 2.13E-45 |
| SNU 24 hours | hsa-miR-374c-5p | -1.884 | ADM | mRNA | ENSG00000148926.10 | 2.340 | 1.78E-143 |
| SNU 24 hours | hsa-miR-374c-5p | -1.884 | GAS5 | lncRNA | ENSG00000234741.8 | 1.795 | 2.73E-202 |
| SNU 24 hours | hsa-miR-374c-5p | -1.884 | SNHG5 | lncRNA | ENSG00000203875.12 | 1.370 | 1.13E-50 |
| SNU 24 hours | hsa-miR-374c-5p | -1.884 | SNHG20 | lncRNA | ENSG00000234912.12 | 1.176 | 1.34E-23 |
| SNU 24 hours | hsa-miR-32-3p | -1.821 | YOD1 | mRNA | ENSG00000180667.10 | 1.658 | 1.06E-111 |
| SNU 24 hours | hsa-miR-32-3p | -1.821 | TNFAIP3 | mRNA | ENSG00000118503.15 | 2.316 | 3.47E-10 |
| SNU 24 hours | hsa-let-7b-3p | -1.541 | KLF4 | mRNA | ENSG00000136826.15 | 1.572 | 1.17E-31 |
| SNU 24 hours | hsa-let-7b-3p | -1.541 | ADRB2 | mRNA | ENSG00000169252.5 | 1.743 | 9.09E-48 |
| SNU 24 hours | hsa-let-7b-5p | -1.541 | SNHG12 | lncRNA | ENSG00000197989.14 | 1.092 | 1.50E-21 |
| SNU 24 hours | hsa-let-7b-5p | -1.541 | LMCD1-AS1 | lncRNA | ENSG00000227110.7 | 1.189 | 5.83E-03 |
| SNU 24 hours | hsa-let-7b-5p | -1.541 | CARMN | lncRNA | ENSG00000249669.10 | 1.637 | 1.11E-04 |
| SNU 24 hours | hsa-miR-195-5p | -1.456 | VEGFA | mRNA | ENSG00000112715.22 | 1.448 | 2.13E-45 |
| SNU 24 hours | hsa-miR-195-5p | -1.456 | ADRB2 | mRNA | ENSG00000169252.5 | 1.743 | 9.09E-48 |
| SNU 24 hours | hsa-miR-195-5p | -1.456 | SNHG12 | lncRNA | ENSG00000197989.14 | 1.092 | 1.50E-21 |
| SNU 24 hours | hsa-miR-195-5p | -1.456 | EPB41 L4A-AS1 | lncRNA | ENSG00000224032.7 | 2.170 | 4.36E-34 |
| SNU 24 hours | hsa-miR-195-5p | -1.456 | AZIN1-AS1 | lncRNA | ENSG00000253320.7 | 1.070 | 2.01E-03 |
| SNU 24 hours | hsa-miR-195-5p | -1.456 | PVT1 | lncRNA | ENSG00000249859.11 | 1.264 | 4.13E-79 |
| SNU 24 hours | hsa-miR-195-5p | -1.456 | LINC01578 | lncRNA | ENSG00000272888.7 | 1.446 | 4.59E-72 |
| SNU 24 hours | hsa-miR-34a-5p | -1.316 | KLF4 | mRNA | ENSG00000136826.15 | 1.572 | 1.17E-31 |
| SNU 24 hours | hsa-miR-34a-5p | -1.316 | HSPA1B | mRNA | ENSG00000204388.7 | 1.676 | 2.82E-82 |
| SNU 24 hours | hsa-miR-34a-5p | -1.316 | SNHG7 | lncRNA | ENSG00000233016.7 | 1.116 | 1.01E-40 |
| SNU 24 hours | hsa-miR-5701 | 1.535 | SYNGR3 | mRNA | ENSG00000127561.15 | -1.505 | 1.63E-08 |
| SNU 24 hours | hsa-miR-5701 | 1.535 | RFLNB | mRNA | ENSG00000183688.4 | -1.340 | 1.86E-27 |
| SNU 24 hours | hsa-miR-12136 | 3.334 | ACVR2B | mRNA | ENSG00000114739.14 | -1.075 | 3.21E-13 |
| SNU 24 hours | hsa-miR-12136 | 3.334 | NR4A2 | mRNA | ENSG00000153234.14 | -1.754 | 9.17E-06 |
| SNU 24 hours | hsa-miR-12136 | 3.334 | CSPG5 | mRNA | ENSG00000114646.10 | -1.089 | 1.71E-08 |
| SNU 24 hours | hsa-miR-12136 | 3.334 | AREG | mRNA | ENSG00000109321.11 | -1.016 | 2.62E-03 |
| SNU 24 hours | hsa-miR-12136 | 3.334 | NRARP | mRNA | ENSG00000198435.4 | -1.763 | 3.74E-12 |
| SNU 24 hours | hsa-miR-12136 | 3.334 | MAF | mRNA | ENSG00000178573.7 | -1.748 | 5.31E-04 |
| SNU 24 hours | hsa-miR-4492 | 8.427 | IGFBP5 | mRNA | ENSG00000115461.5 | -1.073 | 2.38E-18 |
| SNU 24 hours | hsa-miR-4488 | 13.091 | PDGFB | mRNA | ENSG00000100311.17 | -1.101 | 1.09E-51 |