Table 5.
Univariate and multivariate cox regression analysis for chemoresistance rate
| Variables |
Univariate analysis
|
Multivariate analysis
|
||
|
HR (95%CI)
|
P value
|
HR (95%CI)
|
P value
|
|
| Age (≥ 60/< 60), years | 0.872 (0.663-1.025) | 0.843 | ||
| Gender (male/female) | 1.004 (0.593-1.118) | 0.703 | ||
| BMI > 24 kg/m2 (present/absent) | 1.931 (1.658-2.405) | 0.007 | ||
| History of DM (present/absent) | 0.997 (0.556-1.200) | 0.581 | ||
| History of smoke (present/absent) | 1.074 (0.665-1.209) | 0.648 | ||
| History of drinking(present/absent) | 0.837 (0.425-1.102) | 0.431 | ||
| Hypertension (present/absent) | 0.915 (0.503-1.220) | 0.549 | ||
| Cardiovascular disease (present/absent) | 1.025 (0.694-1.280) | 0.331 | ||
| CEA (≥ 5/< 5), μg/mL | 1.231 (0.994-1.398) | 0.223 | ||
| CA19-9 (≥ 37/< 37), ng/mL | 1.096 (0.603-1.222) | 0.387 | ||
| T stage (4/3) | 1.331 (0.967-1.438) | 0.198 | ||
| N stage (2/1) | 1.669 (1.408-2.015) | 0.019 | 1.594 (1.335-1.891) | 0.041 |
| Tumor location (RCC/LCC) | 1.330 (0.894-1.505) | 0.097 | ||
| Tumor size (≥ 4.5/< 4.5), cm | 1.205 (0.983-1.483) | 0.105 | ||
| Tumor differentiation (PD/MD) | 1.606 (1.493-1.994) | 0.013 | 1.499 (1.308-1.837) | 0.028 |
| Vascular invasion (present/absent) | 1.999 (1.784-2.391) | < 0.001 | 1.803 (1.647-2.089) | 0.009 |
| Perineural invasion (present/absent) | 1.347 (1.033-1.688) | 0.124 | ||
| FPG (≥ 7/< 7), mmol/L | 2.558 (2.147-3.669) | < 0.001 | 2.214 (1.980-3.014) | 0.005 |
| HbA1c (≥ 7/< 7), % | 2.867 (2.504-3.771) | < 0.001 | 2.449 (2.101-3.338) | 0.009 |
HR: Hazard ratio; CI: Confidence interval; BMI: Body mass index; DM: Diabetes mellitus; CEA: Carcinoembryonic antigen; CA19-9: Carbohydrate antigen 199; LCC: Left-side colon cancer; RCC: Right-side colon cancer; MD: Moderately differentiated; PD: Poorly differentiated; FPG: Fasting plasma glucose; HbA1c: Glycosylated hemoglobin.