Table 1.
Baseline demographic profiles and characteristics related to pegylated interferon response
|
HC (n = 20)
|
SR (n = 16)
|
NSR (n = 44)
|
P value
|
|
| Age (years) | 28.17 ± 0.25 | 26.00 ± 4.94 | 28.86 ± 8.32 | 0.260 |
| Gender (male/female) | 10/10 | 6/10 | 29/15 | 0.048a |
| Weight (kg) | 56.26 ± 4.20 | 57.54 ± 9.12 | 63.51 ± 11.03 | 0.097 |
| ALT (IU/mL) | 24.97 ± 6.47 | 205.55 ± 69.38 | 185.5 ± 103.61 | 0.530 |
| HBV DNA (log10 IU/mL) | n.d | 7.73 ± 0.61 | 7.94 ± 1.15 | 0.530 |
| HBsAg (log10 IU/mL) | Negative | 4.13 ± 0.46 | 4.44 ± 0.56 | 0.087 |
| Anti-HBs positive | 12 | 0 | 0 | n.d |
| HBeAg (log10 COI) | n.d | 2.90 ± 0.62 | 3.26 ± 0.46 | 0.044a |
| IL-21 (pg/mL) | 12.31 ± 5.42 | 91.27 ± 188.34 | 105.30 ± 379.75 | 0.901 |
| CXCR5+ (%) | 12.11 ± 4.00 | 17.39 ± 8.11 | 16.04 ± 8.68 | 0.639 |
| PD-L1+ (%) | 8.65 ± 1.94 | 12.57 ± 9.55 | 18.31 ± 10.97 | 0.113 |
| CXCR5+CD8+ (%) | 5.50 ± 2.43 | 3.41 ± 3.00 | 1.47 ± 1.34 | 0.042a |
| CXCR5+CD4+ (%) | 6.62 ± 1.06 | 14.43 ± 2.52 | 13.98 ± 1.39 | 0.867 |
| PDL1+CD8+ (%) | 7.75 ± 1.21 | 5.07 ± 3.22 | 8.59 ± 8.46 | 0.061 |
| PDL1+CD4+ (%) | 1.29 ± 0.23 | 7.95 ± 1.75 | 7.95 ± 1.40 | 0.812 |
a
P < 0.05.
Data are shown as mean ± SE. ALT: Alanine aminotransferase; HC: Healthy control; SR: Serologic response; NSR: Non-serologic response; n.d.: Not determined; HBV: Hepatitis B virus; PD-L1: Programmed death-ligand 1; IL-21: Interleukin-21; CXCR5: C-X-C chemokine receptor type 5.