Table 1.
Demographic and clinical data of all patients, n (%)
| Characteristics |
First-line treatment, n = 250 |
Rescue treatment, n = 130 |
P value |
| Age in years | 65.3 ± 4.4 | 65.1 ± 3.6 | 0.6000 |
| Range | 60-82 | 60-76 | |
| Sex as M/F | 106/144 | 60/70 | 0.5500 |
| Body weight in kg | 65.5 ± 11.3 | 65.8 ± 10.8 | 0.8000 |
| BMI in kg/m2 | 24.0 ± 3.4 | 23.7 ± 2.9 | 0.3700 |
| Cigarette smoking | 31 (12.4) | 15 (11.5) | 0.9300 |
| Alcohol drinking | 35 (14.0) | 27 (20.8) | 0.1200 |
| Family history of gastric cancer | 15 (6.0) | 15 (11.5) | 0.0900 |
| Endoscopy diagnosis | |||
| Gastritis | 193 (77.2) | 97 (77.2) | 0.6600 |
| CSG | 108 (43.2) | 32 (24.6) | 0.0006c |
| CAG | 85 (34.0) | 65 (50.0) | 0.0035b |
| Peptic ulcer | 51 (20.4) | 27 (20.8) | 1.0000 |
| Gastric ulcer | 14 (5.6) | 11 (4.4) | 0.4000 |
| Duodenal ulcer | 27 (10.8) | 16 (6.4) | 0.7900 |
| Complex (gastric and duodenal) ulcer | 10 (4.0) | 0 (0.0) | 0.0180a |
| Gastric cancer | 1 (0.4) | 1 (0.8) | 1.0000 |
| MALToma | 3 (1.2) | 0 (0.0) | 0.5500 |
| Gastric hyperplastic polyp | 2 (0.8) | 5 (3.8) | 0.0490a |
| Combined diseases | 1.8 ± 1.4 | 1.8 ± 1.4 | 0.9020 |
| 0 | 53 (21.2) | 26 (20.0) | 0.8900 |
| 1 | 61 (24.4) | 34 (26.1) | 0.8000 |
| 2 | 64 (25.6) | 35 (26.9) | 0.8800 |
| ≥ 3 | 72 (28.8) | 35 (16.9) | 0.7900 |
| Combined medicine | 1.3 ± 1.6 | 1.5 ± 1.7 | 0.3400 |
| 0 | 99 (39.6) | 45 (34.6) | 0.4000 |
| 1 | 59 (23.6) | 36 (27.7) | 0.4500 |
| 2 | 40 (16.0) | 17 (13.1) | 0.5400 |
| ≥ 3 | 52 (20.8) | 32 (24.6) | 0.4700 |
| Comorbidity | |||
| Hypertension | 89 (35.6) | 49 (37.7) | 0.7700 |
| Diabetes mellitus | 45 (18.0) | 20 (15.4) | 0.6200 |
| Hyperlipidemia | 88 (35.2) | 33 (25.4) | 0.0700 |
| Heart disease | 32 (12.8) | 15 (11.5) | 0.8500 |
| Lung disease | 10 (4.0) | 5 (3.8) | 1.0000 |
| Liver disease | 28 (11.2) | 12 (9.2) | 0.6800 |
| Renal disease | 13 (5.2) | 7 (5.4) | 1.0000 |
| Cerebrovascular disease | 10 (4.0) | 7 (5.4) | 0.6000 |
| Autoimmune disease | 24 (9.6) | 9 (6.9) | 0.4500 |
| Hypersensitivity disease | 4 (1.6) | 4 (3.1) | 0.4500 |
| Other malignant tumor | 25 (10.0) | 19 (14.6) | 0.2400 |
| Adherence | 247 (98.8) | 128 (98.5) | 1.0000 |
| Adverse events | 23 (9.2); 95%CI: 6.2%-13.4% | 13 (10.0); 95%CI: 4.8%-15.2% | 1.0000 |
| Eradication rate | 95.6% (239/250); 95%CI: 93.0%-98.1% | 89.2% (116/130); 95%CI: 83.9%-94.6% | 0.0300a |
a
P < 0.05.
b
P < 0.01.
c
P < 0.001.
Data are mean ± SD unless otherwise indicated. Cigarette smoking was defined by consumption of > 5 cigarettes a day or > 1 cigarette pack/week consumed in the past 6 months. A family history of gastric cancer was defined as a gastric cancer diagnosis in a first-degree relative (such as a parent, sibling, or child). Alcohol drinking was defined by > 50 g of alcohol/day consumed in the past 6 months. Compliance was defined by > 80% of tablets taken as instructed. BMI: Body mass index; CSG: Chronic superficial gastritis; CAG: Chronic astrophic gastritis; F: Female; M: Male; MALToma: Mucosa-associated lymphoid tissue lymphoma.