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Gastroesophageal reflux disease. A: Factors causing gastroesophageal reflux disease (GERD); B: Factors associated with GERD symptoms; C: Symptoms/conditions associated with GERD. LES: Lower esophageal sphincter; NSAIDS: Nonsteroidal anti-inflammatory drugs; TLESR: Transient lower esophageal sphincter relaxation.
