Table 1.
Patient’s clinical characteristics and a comparison according to the presence of prolonged dependence on mechanical ventilation among critically ill patients with orthopaedic trauma
| Clinical characteristics | Overall | Prolonged dependence on mechanical ventilation | P | |
|---|---|---|---|---|
| No | Yes | |||
| n | 1400 | 1181 | 219 | |
| Demographics | ||||
| Age (years, median [IQR]) | 55.00 [36.00, 73.00] | 55.00 [35.00, 73.20] | 56.00 [40.00, 72.00] | 0.832 |
| Gender (male/female, %) | 910/490 (65.0/35.0) | 759/422 (64.3/35.7) | 151/68 (68.9/31.1) | 0.209 |
| Addiction | ||||
| Alcohol abuse (no/yes, %) | 1246/154 (89.0/11.0) | 1053/128 (89.2/10.8) | 193/26 (88.1/11.9) | 0.740 |
| Tobacco use disorder (no/yes, %) | 1268/132 (90.6/9.4) | 1070/111 (90.6/9.4) | 198/21 (90.4/9.6) | 1.000 |
| Laboratory examination | ||||
| Hemoglobin (g/dL, median [IQR]) | 12.30 [10.80, 13.83] | 12.40 [10.80, 13.80] | 12.30 [10.80, 13.90] | 0.765 |
| Glucose (mg/dL, median [IQR]) | 137.70 [115.00, 171.00] | 134.00 [114.00, 165.00] | 150.00 [128.00, 188.00] | < 0.001 |
| Hematocrit (%, median [IQR]) | 36.25 [31.90, 40.12] | 36.30 [31.90, 40.10] | 36.10 [31.95, 40.70] | 0.723 |
| Platelet count (K/uL, median [IQR]) | 237.50 [187.00, 296.00] | 238.00 [186.00, 296.00] | 232.00 [190.50, 287.00] | 0.581 |
| Injury information | ||||
| Spine fracture (no/yes, %) | 694/706 (49.6/50.4) | 612/569 (51.8/48.2) | 82/137 (37.4/62.6) | < 0.001 |
| Pelvic fracture (no/yes, %) | 1125/275 (80.4/19.6) | 957/224 (81.0/19.0) | 168/51 (76.7/23.3) | 0.166 |
| Low limb fracture (no/yes, %) | 881/519 (62.9/37.1) | 728/453 (61.6/38.4) | 153/66 (69.9/30.1) | 0.025 |
| Upper limb fracture (no/yes, %) | 906/494 (64.7/35.3) | 775/406 (65.6/34.4) | 131/88 (59.8/40.2) | 0.115 |
| Vital signs | ||||
| pO2 (mmHg, median [IQR]) | 177.50 [96.00, 300.25] | 183.00 [99.00, 306.00] | 149.00 [81.50, 267.00] | 0.006 |
| pCO2 (mmHg, median [IQR]) | 42.30 [38.00, 49.00] | 42.00 [37.00, 49.00] | 44.80 [39.00, 53.00] | < 0.001 |
| pH (unit, median [IQR]) | 7.34 [7.27, 7.40] | 7.34 [7.28, 7.40] | 7.31 [7.23, 7.38] | < 0.001 |
| Heart rate (BPM, median [IQR]) | 89.00 [76.00, 104.00] | 88.00 [75.00, 103.00] | 94.00 [77.00, 110.00] | 0.006 |
| Respiratory rate (BPM, median [IQR]) | 17.00 [14.00, 21.00] | 17.00 [14.00, 20.00] | 19.00 [15.00, 24.00] | < 0.001 |
| Vasopressors (no/yes, %) | 847/553 (60.5/39.5) | 763/418 (64.6/35.4) | 84/135 (38.4/61.6) | < 0.001 |
| Severity of disease | ||||
| OASIS (median [IQR]) | 35.00 [31.00, 41.00] | 35.00 [30.00, 41.00] | 36.00 [31.00, 41.00] | 0.150 |
| SAPSII (median [IQR]) | 33.00 [24.00, 43.00] | 32.00 [23.00, 43.00] | 36.00 [27.00, 45.00] | < 0.001 |
| SOFA (median [IQR]) | 4.00 [2.00, 6.00] | 3.00 [2.00, 6.00] | 5.00 [2.00, 7.00] | < 0.001 |
| Comorbidities | ||||
| Hypertension (no/yes, %) | 953/447 (68.1/31.9) | 799/382 (67.7/32.3) | 154/65 (70.3/29.7) | 0.485 |
| Diabetes (no/yes, %) | 1158/242 (82.7/17.3) | 987/194 (83.6/16.4) | 171/48 (78.1/21.9) | 0.061 |
| Obesity (no/yes, %) | 1331/69 (95.1/4.9) | 1130/51 (95.7/4.3) | 201/18 (91.8/8.2) | 0.023 |
IQR, Interquartile range; BPM, Beats per minute; OASIS, Oxford acute severity of illness score; SAPS II, Simplified acute physiology score II; SOFA, Sequential organ failure assessment score