Table 3.
Changes in the primary effectiveness indicators of each subgroup compared to baseline
| The change of PANSS total score | 1 week (n = 133) |
2 weeks (n = 125) |
4 weeks (n = 113) |
8 weeks (n = 86) |
12 weeks (n = 61) |
|---|---|---|---|---|---|
| Agitation group | –15.72 (9.40) | –32.18 (17.75) | –43.85 (22.60) | –53.53 (26.87) | –57.42 (30.80) |
| No-agitation group | –9.84 (12.181) | –20.26 (14.56) | –27.00 (17.63) | –29.70 (18.42) | –30.20 (19.40) |
| Agitation VS No-agitation group |
T = 0.89 P = 0.37 |
T = 2.64 P = 0.009 |
T = 3.57 P < 0.001 |
T = 4.93 P < 0.001 |
T = 5.26 P < 0.001 |
| First-episode group | –16.16 (9.63) | –31.47 (15.87) | –42.06 (19.78) | –48.18 (23.87) | –51.76 (28.74) |
| Chronic group | –10.34 (11.79) | –22.21 (16.91) | –30.21 (21.57) | –35.87 (25.38) | –36.99 (27.07) |
| First-episode VS Chronic group |
T = 1.91 P = 0.06 |
T = 2.58 P = 0.01 |
T = 2.80 P = 0.006 |
T = 2.50 P = 0.01 |
T = 2.77 P = 0.006 |
| Male group | −14.18 (1.78) | −23.23 (2.46) | −30.82(3.07) | −35.61 (3.59) | −36.58 (4.00) |
| Female group | −12.57 (1.18) | −27.56 (1.65) | −37.13 (2.06) | −43.43 (2.41) | −45.92 (2.69) |
| Male VS Female group |
T = 0.75 P = 0.45 |
T = −1.47 P = 0.15 |
T = −1.71 P = 0.09 |
T = −1.81 P = 0.07 |
T = −1.94 P = 0.06 |
| Youth group, | −14.37 (3.09) | −30.45 (4.37) | −45.22 (5.43) | −48.30 (6.39) | −50.61 (7.18) |
| Adult group | −12.51 (1.02) | −25.32 (1.43) | −33.65 (1.78) | −39.77 (2.10) | −41.75 (2.36) |
| Youth VS Adult group |
T = 0.57 P = 0.57 |
T = 1.12 P = 0.27 |
T = 2.02 P = 0.045 |
T = 1.27 P = 0.21 |
T = 1.17 P = 0.24 |
Data are reported as mean (SD). SD, standard deviation. PANSS, Positive and Negative Syndrome Scale. Data were analyzed with the last observation carried forward (LOCF) method