Table 1.
Experimental protocols
| # | Animal strain | Groups | Time | Diet | Analysis |
|---|---|---|---|---|---|
| 1 |
Male ApoE-/- |
DE | 2 wk | Chow |
Transcriptomics, liver, n = 8/group |
| FA | 2 wk | ||||
| DE + FA |
2 wk + 1 wk |
||||
| 2 |
Male ApoE-/- |
DE | 2 wk | Chow |
Metabolomics, liver, n = 5/group |
| FA | 2 wk |
Transcriptomic analysis was conducted in ApoE null mice exposed to diesel exhaust (DE) or filtered air (FA) for 2 weeks (wk), or DE for 2 weeks followed by one week of FA (DE + FA) in Protocol 1. Livers were harvested for RNA extraction and Illumina microarrays, n = 8 per group. Metabolomics was performed on livers from ApoE null mice exposed to DE or FA for two weeks in Protocol 2. n = 5 per group