Table 2.
DE exposure alters multiple pathways in the liver
| Gene Set Name | p-value | FDR q-value | Enrichment |
|---|---|---|---|
| Metabolism of lipids and lipoproteins | 8.47E-14 | 1.30E-10 | 6.5 |
| Lysosome | 3.67E-11 | 8.72E-09 | 12.8 |
| Transcription | 8.02E-11 | 1.69E-08 | 4.4 |
| Fatty acid triacylglycerol and ketone body metabolism | 2E-10 | 3.81E-08 | 9.9 |
| Response to stress | 5.51E-10 | 8.73E-08 | 5.2 |
| Negative regulation of programmed cell death | 5.97E-10 | 8.73E-08 | 10.3 |
| RNA metabolic process | 9.56E-10 | 1.30E-07 | 4.0 |
| Oxidative phosphorylation | 1.9E-09 | 2.26E-07 | 10.6 |
| Metabolism of amino acids and derivatives | 1.82E-08 | 1.38E-06 | 7.7 |
| TCA cycle and respiratory electron transport | 3.62E-07 | 2.09E-05 | 8.4 |
| Cellular carbohydrate metabolic process | 1.32E-06 | 6.25E-05 | 8.5 |
| Valine, leucine and isoleucine degradation | 1.82E-06 | 7.87E-05 | 16.2 |
| PPARA activates gene expression | 2.94E-06 | 1.19E-04 | 9.2 |
| Caraboxylic acid metabolic process | 3.03E-06 | 1.2E-04 | 6.7 |
The table shows the 14 top gene pathways significantly affected by DE exposures using the GSEA/MSigDB, p < 0.05, FDR < 0.05