Table 1.

Metabolic modulation for T cell metabolism in the kidney.

Drug	T cell subsets	Target	Effect	Disease model	Ref
2-Deoxy-D-glucose	CD4+ T cell	Glycolysis	Cytokine production↓	Lupus	Yin et al. (105)
Metformin	CD4+ T cell	OXPHOS	Cytokine production↓	Lupus	Yin et al. (105)
CG-5	Th1, Th17	GLUT	Differentiation↓	Lupus	Li et al. (23)
KN93	Th17	GLUT, glycolysis	Differentiation↓	Lupus	Koga et al. (114)
FK866	CD4+ T cell	Glycolysis, OXPHOS	Effector function↓	Lupus	Li et al. (119)
canagliflozin	CD4+ T cell	Glycolysis, OXPHOS, glutaminolysis	Effector function↓, Proliferation↓	Lupus	Jenkins et al. (122)
JHU083	CD4+ T cell, CD8+ T cell	glutaminolysis	Activation, proliferation↓	AKI	Lee et al. (126)

↓, indicates a decrease or reduction.