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. Author manuscript; available in PMC: 2025 Dec 1.
Published in final edited form as: Drug Alcohol Depend. 2024 Oct 29;265:112473. doi: 10.1016/j.drugalcdep.2024.112473

Table 2.

Proportion of Adolescent Brain Cognitive Development (ABCD) Study participants within each gender category who have experimented (lifetime and new experimentation at Year 3) with each type of substance use.a

Total sample “Are you transgender?” Felt gender categoriesb
No Maybe Yes Cisgender/SCFG 1-STEP 2-STEP Minority Group
Substance use characteristics % % % % % % % %
Substance use (lifetime experimentation)
Alcohol 15.3 % 15.2 % 24.8 % 29.0 % 14.6 % 18.2 % 18.8 % 17.4 %
Nicotine 2.8 % 2.8 % 1.1 % 7.4 % 2.7 % 2.5 % 3.5 % 3.9 %
Cannabis 2.0 % 1.9 % (−) 9.1 % 1.7 % 1.5 % 2.3 % 5.3 %
Any substance 28.2 % 27.9 % 38.7 % 40.9 % 26.9 % 32.5 % 36.2 % 31.5 %
Substance use (new experimentation at Year 3)
Alcohol 4.7 % 4.7 % 4.9 % 6.0 % 4.1 % 8.0 % 7.3 % 5.2 %
Nicotine 1.8 % 1.8 % (−) 6.1 % 1.7 % 1.8 % 2.7 % 2.5 %
Cannabis 1.2 % 1.2 % (−) 5.9 % 1.1 % 1.0 % 1.9 % 2.8 %
Any substance 12.6 % 12.5 % 8.7 % 19.3 % 11.3 % 18.0 % 21.1 % 14.5 %
a

ABCD Study sampling weights were applied based on the American Community Survey from the US Census; (−) indicates no data available for the subgroup.

b

Categories represent increasing gender diverse identities based on questions of adolescents’ felt gender. In increasing order, categories are cisgender/SCFG, 1-STEP, 2-STEP, and minority group from Potter et al. (2021); SCFG = sex congruent felt gender