Table 1.

Results of two-step Mendelian randomization mediation analysis.

Exposure	Mediator	Outcome	X-M		M-Y		X-Y		Effect rate
			OR (95%CI)	P	OR (95%CI)	P	OR (95%CI)	P
Superpathway of L-tryptophan biosynthesis	CD14+ CD16+ monocyte Absolute Count	AIH	0.856 (0.759,0.965)	0.011	0.700 (0.561,0.865)	0.001	1.380 (1.095,1.738)	0.006	17.47%
Species.Ruminococcus_obeum	CD62L-CD86+ myeloid Dendritic Cell %Dendritic Cell	PSC	0.730 (0.615,0.868)	0.0003	1.341 (1.052,1.708)	0.018	0.753 (0.593,0.956)	0.020	32.47%

X, exposure; M, mediator; Y, outcome; AIH, Autoimmune Hepatitis; PSC, Primary Sclerosing Cholangitis.