Table 3.
Multivariate analyses of the association between Hp genotype and events of CVD in patients with RA.
| Adjusted matched OR | 95% CI | p | |
|---|---|---|---|
| Hp 2-2 genotype | 1.13 | 1.01–1.27 | 0.033 |
| Age | 1.06 | 1.05–1.07 | <0.001 |
| Smoking | 1.43 | 1.22–1.68 | <0.001 |
| Diabetes | 1.21 | 1.04–1.42 | 0.013 |
| Hypertension | 2.78 | 2.42–3.19 | <0.001 |
| Hyperlipidemia | 2.77 | 2.43–3.14 | <0.001 |
| Positive anti-CCP | 3.27 | 2.80–3.82 | <0.001 |
| DAS-28 | |||
| Remission/low disease activity | reference | — | <0.001 |
| Moderate/severe disease activity | 2.21 | 1.86–2.61 | |
Hp, haptoglobin; RA, rheumatoid arthritis; OR, odds ratio; 95% CI, 95% confidence interval; CCP, cyclic-citrullinated peptide; DAS-28, disease activity score 28; CVD, cardiovascular disease. Bold values indicates statistically significant.