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Effect of green synthesized CuO nanoparticles of the B. amplexicaulis root extract on (A) body weight; (B) paw thickness; (C) mobility score; and (D) joint stiffness score. Control negative (NC), control positive (PC), standard dose (SD), plant extract (T1), low-dose nanoparticles (T2), and high-dose nanoparticles (T3). Significance value: *p < 0.05, **p < 0.001, and ***p < 0.0001. Comparison of the disease group with other groups.
