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. 2025 Jan 1;16(2):406–416. doi: 10.7150/jca.102360

Figure 3.

Figure 3

NK cell failure is induced by exosomal miR-552-5p via the PD-1/PD-L1 axis. (A) Flow cytometry analysis of PD-L1 expression levels on the surface of NK cells in the peripheral blood of nude mice from each group. (B-D) Exosomal miR-552-5p inhibits aPD-L1-induced reduction of NK cell proportions and activation receptors NKp46 and NKG2D. (E-G) Inhibition of aPD-L1 on the downregulation of Granzyme B, Perforin, and IFN-γ production in NK cells from nude mice's peripheral blood caused by exosomal miR-552-5p generated from gastric cancer cells (*p < 0.05; **p < 0.01; ***p < 0.001).