Fig. 1. GREML-LDMS estimates from WES data stratified in 8 bins, including 2 linkage disequilibrium (LD) bins for each of the 4 minor allele frequency (MAF) bins, correcting for 160 PCs (20 * 8 bins) for MAGIC and UKB.

a Estimate for HM with $h_{WES}^2$ at 0.53 (s.e. = 0.06) in MAGIC (n = 12,600). b Estimate for HM with $h_{WES}^2$ at 0.21 (s.e. = 0.10) in UKB (n = 8682). We stratified SNPs into 4 MAF bins (0.0001 < MAF < 0. 0010, 0.001 < MAF < 0.010, 0.01 < MAF < 0.10 and 0.1 < MAF < 0.5). Each of the 4 MAF bins was divided into two more bins, one for variants with LD scores above the median value of the variants in the bin (high-LD bin) and one for variants with LD score below the median (low-LD bin) (Supplementary Table 3). Error bars indicate standard errors (SE).