Table 1.

The performance metrics of the GRS in the testing cohorts

Models	OR per s.d. (95% CI), P	AUC	PRS threshold	OR (95% CI), P	Prevalence of HM
cvGRS	3.74 (3.19–4.44), 3.27 × 10–55	0.819	Top 20% versus other 80%	9.58 (6.43–14.68), 5.70 × 10–41	0.86
			Top 10% versus other 90%	10.93 (5.92–22.05), 7.11 × 10–23	0.90
			Top 5% versus other 95%	9.95 (4.24–28.50), 1.94 × 10–11	0.90
			Top 2% versus other 98%	7.19 (2.13–37.86), 2.4 × 10−4	0.87
			Top 1% versus other 99%	5.05 (1.07–47.61), 0.037	0.83
rvGRS	2.24 (1.99–2.54), 4.92 × 10–38	0.759	Top 20% versus other 80%	9.21 (6.21–14.04), 5.33 × 10–40	0.86
			Top 10% versus other 90%	9.96 (5.50–19.54), 7.25 × 10–22	0.89
			Top 5% versus other 95%	9.95 (4.24–28.50), 1.94 × 10–11	0.90
			Top 2% versus other 980%	7.19 (2.13–37.86), 2.4 × 10–4	0.87
			Top 1% versus other 99%	11.15 (1.61–480.32), 0.006	0.91
ExGRS	3.51 (3.05–4.07), 1.31 × 10−65	0.856	Top 20% versus other 80%	12.45 (8.07–19.86), 3.58 × 10-47	0.89
			Top 10% versus other 90%	15.13 (7.59–34.31), 3.74 × 10−26	0.92
			Top 5% versus other 95%	15.57 (5.70–59.48), 1.47 × 10–13	0.93
			Top 2% versus other 980%	7.19 (2.13–37.86), 2.4 × 10–4	0.87
			Top 1% versus other 99%	11.15 (1.61–480.32), 0.006	0.91