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. 2005 Jul;73(7):3903–3911. doi: 10.1128/IAI.73.7.3903-3911.2005

FIG. 2.

FIG. 2.

Liver histological reaction in infected WT BALB/c mice on day + 12 and day + 21. Treatment (see Table 1, footnote a) was started on day + 12. (A) Early granuloma assembly on day + 12. (B to F) Day + 21 granulomatous responses in untreated mice (B) or mice treated with rat IgG (0.5 mg, once on day + 12) (C), anti-IL-10R (D), TGF-βRII-Fc (E), or IL-13Rα2-Fc (F). Day + 21 granulomas in anti-IL-10R-treated mice (D) show increased maturation (cellularity and epitheloid changes) and few parasites. In contrast, developing granulomas in all other mice show numerous amastigotes (arrows). Magnification, ×180 (original magnification, ×200).