FIG. 5.

Impaired initial liver granuloma assembly and maturation in L. donovani-infected IL-13Rα2^−/− mice. (A and B) WT BALB/c mice show developing granulomas 2 weeks after infection (A) and mature granulomas containing few amastigotes at week 4 (B). (C and D) In contrast, in IL-13Rα2^−/− mice, there is little or no initial inflammatory response at week 2 (arrows indicate four infected foci) (C); granulomas at week 4 (D) are primarily developing and contain abundant parasites (arrows). Magnification, ×180 (original magnification, ×200).