TABLE 2.

Effect of cytokine antagonists on efficacy of low-dose antimony (Sb)^a

Pretreatment	Sb	Liver parasite burden (LDU)		% Killing
		Day + 14	Day + 21b
None	−	989 ± 87	1,160 ± 67	0
	+		851 ± 90	14
Anti-IL-10R	−		820 ± 65	17
	+		217 ± 32**	72
Rat IgG	−		1,239 ± 147	0
	+		940 ± 119	5
Anti-IL-4	−		1,122 ± 121	0
	+		890 ± 99	10
TGF-βIIR-Fc	−		930 ± 78	6
	+		771 ± 89	22
IL-13Rα2-Fc	−		900 ± 106	9
	+		732 ± 66	26

^aTreatment starting day + 12 was as in Table 1 legend, except a reduced dose (0.1 mg) of anti-IL-10R and rat IgG was used (see Materials and Methods). Suboptimal Sb (50 mg/kg) was given once on day + 14. Control IgG for the other antagonists did not increase the effect of Sb, and data have been omitted for brevity. Results are from two to three experiments and indicate mean ± SEM values for 7 to 12 mice per time point.

^b**, P, < 0.05 versus day + 14 value.