TABLE 3.
Susceptibilities of M. catarrhalis wild-type strain O35E and mutant O35EkdtA to a panel of hydrophobic agents or a hydrophilic glycopeptide
| Compound (amt or concn) | Zone of growth inhibition for strains (mm)a
|
|
|---|---|---|
| O35E | O35EkdtA | |
| Azithromycin (15 μg) | 29.0 ± 0.5 | 35.4 ± 0.5 |
| Fusidic acid (10 mg/ml) | 29.0 ± 0.9 | 32.5 ± 0.5 |
| Novobiocin (5 μg) | 13.8 ± 0.3 | 16.1 ± 0.3 |
| Polymycin B (300 iu) | 11.5 ± 0.5 | 15.5 ± 0.0 |
| Rifampin (5 μg) | 22.1 ± 0.3 | 29.0 ± 0.5 |
| Vancomycin (5 μg) | <6.0b | 8.2 ± 0.3 |
| Deoxycholate (100 mg/ml) | 22.0 ± 0.9 | 26.8 ± 0.3 |
| Triton X-100 (5% [wt/vol]) | 15.5 ± 0.5 | 24.5 ± 0.5 |
| Tween 20 (5% [vol/vol]) | 11.5 ± 0.5 | 14.2 ± 0.3 |
a
Sensitivity was assessed by measuring the diameter of the zone of growth inhibition in two axes, and the mean value was calculated. Values are the means ± standard deviations. The data represent the averages of three separate experiments.
b
Stands for no inhibition for bacterial growth.