TABLE 3.
Vaginal antibody levels specific for TbpB detected at days 28, 35, and 65a
| Immunization group | Day 28b
|
Day 35
|
Day 65
|
|||
|---|---|---|---|---|---|---|
| IgA | IgG | IgA | IgG | IgA | IgG | |
| TbpB − Ctb | 12.2 ×/÷ 2.9 | 32.5 ×/÷ 1.4f | 6.4 ×/÷ 2.7 | 15.9 ×/÷ 1.5f | 3.5 ×/÷ 1.7 | 2.0 ×/÷ 3.8d |
| TbpA − Ctb + TbpB − Ctb | 8.2 ×/÷ 3.6 | 20.2 ×/÷ 5.5 | 2.6 ×/÷ 2.9 | 20.4 ×/÷ 1.5 | 1.9 ×/÷ 2.9 | 9.7 ×/÷ 4.0e |
| TbpB + Ctb | 0 | 0 | 0 | 0 | 0 | 0 |
| TbpA + TbpB + Ctb | <0.2c | 0 | <0.1d | 1.8 ×/÷ 2.9e | <0.1d | 1.6 ×/÷ 2.7c |
| TbpB | <0.2c | 0 | 0 | 0.5 ×/÷ 1.3c,f | 0 | 0 |
| S.c.g TbpA + TbpB + Ctb | <0.1d | 20.5 ×/÷ 1.8 | <0.1d | 12.9 ×/÷ 1.5 | <0.1d | 15.8 ×/÷ 1.5 |
a
Data are expressed as the geometric mean of the percentage of total corresponding antibody isotype concentrations ± standard deviation.
b
Day 28 is 7 days after final immunization.
c
Only one mouse had detectable TbpB-specific antibodies.
d
Only two mice had detectable TbpB-specific antibodies.
e
Only three mice had detectable TbpA-specific antibodies.
f
n = 4; one mouse removed due to very low total IgG.
g
S.c., subcutaneous.