TABLE 1.
Species (n) and isolatea tested | MIC (μg/ml)
|
FICIb for AMB-MFG | MIC (μg/ml)
|
FICIb for FLC-MFG | |||
---|---|---|---|---|---|---|---|
AMB | MFG | AMB-MFG | FLC | FLC-MFG | |||
C. neoformans (10) | |||||||
FMR 8393 | 1 | 64 | 0.25/16 | 0.5 | 16 | 16/64 | 2 |
FMR 8398 | 1 | 64 | 0.25/16 | 0.5 | 32 | 32/64 | 2 |
FMR 8400 | 0.5 | 64 | 0.12/8 | 0.4 | 16 | 16/64 | 2 |
FMR 8401 | 0.5 | 64 | 0.12/8 | 0.4 | 8 | 2/2 | 0.3 |
FMR 8408 | 0.25 | 64 | 0.12/4 | 0.6 | 2 | 2/64 | 2 |
FMR 8409 | 0.5 | 64 | 0.12/16 | 0.5 | 1 | 1/64 | 2 |
FMR 8411 | 1 | 64 | 0.25/2 | 0.3 | 32 | 4/0.25 | 0.1 |
FMR 8415 | 0.5 | 64 | 0.25/4 | 0.6 | 8 | 8/64 | 2 |
FMR 8416 | 0.5 | 64 | 0.12/16 | 0.5 | 8 | 8/64 | 2 |
FMR 8420 | 0.25 | 64 | 0.12/8 | 0.6 | 4 | 1/16 | 0.5 |
C. gattii (10) | |||||||
FMR 8402 | 0.5 | 64 | 0.12/16 | 0.5 | 64 | 64/64 | 2 |
FMR 8403 | 0.06 | 64 | 0.06/0.06 | 1 | 32 | 32/64 | 2 |
FMR 8404 | 0.5 | 64 | 0.12/0.25 | 0.2 | 64 | 64/64 | 2 |
FMR 8405 | 0.25 | 64 | 0.12/2 | 0.6 | 64 | 64/64 | 2 |
FMR 8406 | 0.5 | 64 | 0.12/0.5 | 0.2 | 32 | 32/64 | 2 |
FMR 8407 | 0.25 | 64 | 0.06/16 | 0.5 | 64 | 64/64 | 2 |
FMR 8410 | 0.25 | 64 | 0.06/16 | 0.5 | 32 | 8/16 | 0.5 |
FMR 8412 | 0.25 | 64 | 0.06/16 | 0.5 | 8 | 2/16 | 0.5 |
FMR 8413 | 0.25 | 64 | 0.06/16 | 0.5 | 32 | 32/64 | 2 |
FMR 8414 | 0.5 | 64 | 0.12/0.25 | 0.2 | 32 | 32/64 | 2 |
FMR, Faculty of Medicine, University of Rovira i Virgili, Reus, Tarragona, Spain.
FICI scores: ≤0.5, synergistic; >0.5 and ≤4, indifferent; >4, antagonistic (14).