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Tag-100-QnrA-His6 fusion protein protects topo IV from quinolone inhibition of decatenation. Reactions of 40 μl were analyzed by agarose gel electrophoresis. Reaction mixtures contained 0.5 μg catenated kinetoplast DNA (lanes 1 to 5), 3.5 nM topo IV (lanes 1 to 5), 18 μM ciprofloxacin (lanes 3 to 5), and purified QnrA at 0.4 μM (lane 3), 0.2 μM (lane 4), or 0.1 μM (lane 5).
