. 2024 Dec 3;87(12):2829–2838. doi: 10.1021/acs.jnatprod.4c01098

Table 1. In Vitro Activity of Beauvericin (1) on L. amazonensis, L. braziliensis, T. cruzi, L929 Fibroblasts, and Bone Marrow-Derived Macrophages^a.

Parasite or host cell/Stage	EC₅₀ or CC₅₀ ± SD (μM)^b	Selectivity index (SI)
L. amazonensis/promastigote	1.2 ± 0.1	14.8
L. amazonensis/intracellular amastigote	0.8 ± 0.1	22.3
L. braziliensis/promastigote	0.9 ± 0.2	19.8
L. braziliensis/intracellular amastigote	0.6 ± 0.1	29.7
Bone marrow-derived macrophages (BMDM)	17.8 ± 0.4	–
T. cruzi/epimastigote	3.4 ± 0.8	13.4
L929 fibroblasts	45.5 ± 0.9	–

Cell viability, measured by the MTT assay, was determined after exposure to different concentrations of 1 for 24 h.

(EC₅₀): 50% effective concentration. (CC₅₀): 50% cytotoxicity concentration. (SD): standard deviation. (SI): BMDM CC₅₀/Leishmania EC₅₀ and L929 CC₅₀/T. cruzi EC₅₀. (−): not applicable.

Table 1. In Vitro Activity of Beauvericin (1) on L. amazonensis, L. braziliensis, T. cruzi, L929 Fibroblasts, and Bone Marrow-Derived Macrophagesa.

Table 1. In Vitro Activity of Beauvericin (1) on L. amazonensis, L. braziliensis, T. cruzi, L929 Fibroblasts, and Bone Marrow-Derived Macrophages^a.