Table 3.
Dynamic alterations in angiopoietin-2 and hypoxia-inducible factor-1α during hepatocarcinogenesis in rats
| Group | n |
Ang-2
|
HIF-1α
|
||
|
Liver (ng/mg)1
|
Serum (μg/L)
|
Liver (ng/mg)1
|
Serum (μg/L)
|
||
| NC | 12 | 69.7 ± 6.0 | 105.2 ± 19.2 | 9.7 ± 2.8 | 206.3 ± 9.6 |
| HD | 18 | 73.2 ± 17.0 | 140.2 ± 25.2 | 12.6 ± 3.2 | 270.2 ± 48.0 |
| LC/PC | 9 | 93.7 ± 11.2a | 203.8 ± 23.8a | 16.9 ± 2.6b | 401.6 ± 89.4b |
| rHCC | 9 | 107.6 ± 9. 8b | 222.4 ± 23.3b | 23.5 ± 8.9b | 445.9 ± 69.5b |
1
ng/per mg liver tissue.
a
P < 0.05, compared with the normal control group.
b
P < 0.01, compared with the normal control group.
Ang-2: Angiopoietin-2; HIF-lα: Hypoxia-inducible factor-1α; NC: Normal control; rHCC: Rat hepatocellular carcinoma; HD: Hepatocyte degeneration; LC: Liver cirrhosis; PC: Precancerosis.