TABLE 4.
Effects of the ODC inhibitors APA, CGP 52622A, and CPG 54169A on the polyamine pattern of P. falciparum-infected RBCs
| Treatment (24 h) | Intracellular polyamine concn (nmol/1010 cells)a
|
||
|---|---|---|---|
| Putrescine | Spermidine | Spermine | |
| Control | 272.4 ± 37.1 | 1,007.8 ± 118.7 | 49.9 ± 5.5 |
| 1 μM APA | 52.6 ± 38.0 | 319.2 ± 180.1 | 69.4 ± 9.9 |
| 2 μM APA | 10.1 ± 4.8 | 222.7 ± 105.4 | 88.8 ± 6.6 |
| Control | 410.2 ± 87.0 | 1,550.5 ± 76.0 | 83.5 ± 3.3 |
| 1 μM CGP 54169A | 91.7 ± 28.5 | 589.2 ± 198.0 | 187.1 ± 35.6 |
| 5 μM CGP 54169A | 23.4 ± 13.3 | 287.5 ± 127.9 | 202.0 ± 59.3 |
| Control | 453.9 ± 100.4 | 888.9 ± 245.7 | 38.9 ± 23.5 |
| 1 μM CGP 52622A | 342.9 ± 99.4 | 641.0 ± 162.1 | 81.5 ± 67.2 |
| 5 μM CGP 52622A | 286.6 ± 85.6 | 489.1 ± 106.3 | 117.7 ± 100.8 |
a
The data are the means ± standard deviations of four to five independent determinations.