TABLE 5.
Effects of the AdoMetDC inhibitors CGP 40215A and MDL 73811 on the polyamine pattern of P. falciparum-infected RBCs
| Treatment | Intracellular polyamine concn (nmol/1010 cells)a
|
||
|---|---|---|---|
| Putrescine | Spermidine | Spermine | |
| 24 h | |||
| Control | 172.9 ± 76.6 | 649.5 ± 129.2 | 24.6 ± 3.4 |
| 1 μM MDL 73811 | 367.3 ± 40.1 | 301.2 ± 22.3 | 29.4 ± 3.4 |
| 5 μM MDL 73811 | 515.0 ± 168.9 | 213.1 ± 25.6 | 33.4 ± 9.2 |
| Control | 334.1 ± 24.7 | 935.3 ± 93.2 | 64.7 ± 6.9 |
| 5 μM CGP 40215A | 262.2 ± 33.2 | 1,182.9 ± 179.6 | 84.5 ± 16.0 |
| 48 h | |||
| Control | 261.8 ± 40.6 | 743.9 ± 68.0 | 39.3 ± 15.6 |
| 1 μM MDL 73811 | 616.2 ± 124.3 | 594.8 ± 120.9 | 17.8 ± 4.4 |
| 5 μM MDL 73811 | 822.6 ± 151.9 | 335.0 ± 117.5 | 13.6 ± 5.0 |
| Control | 479.5 ± 128.1 | 1,045.6 ± 144.6 | 41.1 ± 8.4 |
| 2 μM CGP 40215A | 422.9 ± 124.9 | 1,246.5 ± 110.9 | 46.8 ± 13.0 |
| 4 μM CGP 40215A | 379.7 ± 200.2 | 1,169.3 ± 175.6 | 50.5 ± 14.2 |
a
The data are the means ± standard deviations of three to five independent determinations.