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Effects of various roxithromycin concentrations on NADPH oxidase activation. PMN were incubated with the macrolide for 30 min before stimulation with PMA (2 μg/liter) and isolation of the particulate fraction containing NADPH oxidase. The mean and the standard error of the mean of five independent experiments are indicated by black columns. *, P < 0.01 versus control (100%). The logarithmic concentration-dependent effect is shown in the inset.
