TABLE 1.
MICs of antimicrobial peptides for various gram-negative and gram-positive bacteria
| Species and strain | Relevant feature(s)a | MIC (μg/ml) of:
|
||
|---|---|---|---|---|
| M4 | M5 | M6 | ||
| Escherichia coli ATCC 25922 | Reference strain | 128 | 16 | 8 |
| Escherichia coli W99FI0077 | FQr ESCr (ESBL/SHV type) | 16 | 128 | 8 |
| Escherichia coli W03BG0025 | FQr AGr ESCr (ESBL/CTX-M-15) | NDb | ND | 8 |
| Escherichia coli W03NO0013 | FQr ESCr (ESBL/CTX-M-1) | ND | ND | 8 |
| Pseudomonas aeruginosa ATCC 27853 | Reference strain | 32 | 16 | 4 |
| Pseudomonas aeruginosa 885149 | FQr AGr ESCr CPr (MBL/IMP-13) | 64 | 32 | 8 |
| Pseudomonas aeruginosa 891 | FQr AGr ESCr CPr (MBL/VIM-2) | 64 | 16 | 8 |
| Pseudomonas aeruginosa VA463/98 | FQr AGr ESCr (ESBL/PER-1) | ND | ND | 4 |
| Klebsiella pneumoniae W99FI0057 | ESCr (ESBL/SHV type) | 64 | >128 | 4 |
| Klebsiella pneumoniae W03NO0078 | ESCr (ESBL/CTX-M-1) | ND | ND | 16 |
| Klebsiella pneumoniae W03BG0019 | AGr ESCr (ESBL/CTX-M-15) | ND | ND | 8 |
| Klebsiella oxytoca W99FI00049 | ESCr (ESBL/SHV-12) | ND | ND | 64 |
| Proteus mirabilis W99FI0089 | FQr | ND | ND | >128 |
| Proteus mirabilis W03VA1144 | FQr AGr ESCr (ESBL/PER-1) | ND | ND | 64 |
| Enterobacter aerogenes W03BG0067 | AGr ESCr (ESBL/SHV-5) | ND | ND | 8 |
| Enterobacter cloacae W03AN0041 | ESCr (ESBL/SHV-12) | ND | ND | 4 |
| Morganella morganii W03VA1342 | FQr ESCr (ESBL/CTX-M-1) | ND | ND | >128 |
| Acinetobacter baumannii AB1MG | FQr AGr ESCr (ESBL/TEM-92) | ND | ND | 16 |
| Acinetobacter baumannii AB7MG | FQr AGr ESCr | ND | ND | 32 |
| Citrobacter freundii W99FI00007 | ESCr (ESBL/SHV-12) | ND | ND | 16 |
| Chryseobacterium meningosepticum CCUG4310 | Reference strain | ND | ND | >128 |
| Burkholderia cepacia SMC71 | FQr AGr ESCr | ND | ND | 64 |
| Serratia marcescens W99FI0111 | FQr AGr ESCr (ESBL/SHV-5) | ND | ND | >128 |
| Stenotrophomonas maltophilia PT4/99 | Wild-type profile | ND | ND | >128 |
| Providencia stuartii W03FI0001 | AGr ESCr (ESBL/PER-1) | ND | ND | >128 |
| Staphylococcus aureus ATCC 25923 | Reference strain | 64 | 128 | >128 |
| Staphylococcus aureus MIU-68A | MS | >128 | 128 | 128 |
a
Except for reference strains, the other strains were clinical isolates. Relevant resistance phenotypes and known resistance mechanisms are indicated. FQr, resistance to fluoroquinolones (ciprofloxacin); AGr, resistance to aminoglycosides (gentamicin, amikacin, and/or tobramycin); ESCr, resistance to extended-spectrum cephalosporins (cefotaxime, ceftazidime, and/or cefepime); CPr, resistance to carbapenems (imipenem and/or meropenem); ESBL, extended-spectrum β-lactamase; MBL, metallo-β-lactamase; MS, methicillin susceptible.
b
ND, not determined.