Fig. 6.

The ability of RTRT and CNRT in eliciting abscopal effects. A Schematic of bilateral tumor model construction and irradiation. B Growth curves of irradiated tumors in a bilateral tumor model (n = 5). ^#, RTRT vs Control, P < 0.05. ^####, RTRT vs Control, P < 0.0001. ^****, CNRT vs Control, P < 0.0001. ns indicates no statistical difference. The statistical test was performed using One-way or Two-way ANOVA, followed by Tukey’s multiple comparisons test. C Growth curves of non-irradiated tumors in a bilateral tumor model. ^#, RTRT vs Control, P < 0.05. ^***, CNRT vs Control, P < 0.001. The statistical test was performed using Two-way ANOVA, followed by Tukey's multiple comparisons test. D Kaplan–Meier survival curves were generated of each group mice in the bilateral tumor model, and significance was determined by log-rank (Mantel-Cox) test. ^*, P < 0.05. E Lymphocyte subsets of non-irradiated tumors were analyzed by flow cytometry (n ≥ 5). ns indicates no statistical difference. ^*, P < 0.05. ^**, P < 0.01. ^***, P < 0.001. The statistical test was performed using One-way ANOVA, followed by Tukey’s multiple comparisons test