Table 2.
Association of baseline levels in peripheral blood circulating immune subsets with disease control rate
| nDC, N = 16 | DC, N = 25 | OR (95% CI) | p-value | |
|---|---|---|---|---|
| WBC (×10 9 /L) | 1.07 (0.84,1.40) | 0.592 | ||
| Mean (SD) | 7.45 (2.38) | 7.89 (2.71) | ||
| Median (IQR) | 6.81 (5.62, 8.57) | 8.11 (5.71, 9.15) | ||
| Neutrophil count (×10 9 /L) | 1.08 (0.78,1.53) | 0.656 | ||
| Mean (SD) | 4.89 (1.91) | 5.17 (2.10) | ||
| Median (IQR) | 4.29 (3.83, 5.51) | 4.63 (3.51, 6.19) | ||
| ALC (×10 9 /L) | 0.99 (0.55,1.89) | 0.964 | ||
| Mean (SD) | 1.78 (1.50) | 1.76 (0.80) | ||
| Median (IQR) | 1.25 (1.08, 2.04) | 1.56 (1.33, 2.05) | ||
| NLR | 0.84 (0.58,1.17) | 0.320 | ||
| Mean (SD) | 3.89 (2.68) | 3.26 (1.26) | ||
| Median (IQR) | 3.23 (2.19, 4.17) | 3.36 (2.45, 4.32) | ||
| LMR | 0.91 (0.62,1.27) | 0.548 | ||
| Mean (SD) | 2.99 (2.62) | 2.62 (1.41) | ||
| Median (IQR) | 2.49 (1.67, 3.10) | 2.39 (1.73, 2.88) | ||
| MDSC count (×10 9 /L) | 3.23 (0.19,67.3) | 0.426 | ||
| Mean (SD) | 0.41 (0.19) | 0.47 (0.25) | ||
| Median (IQR) | 0.44 (0.28, 0.53) | 0.49 (0.28, 0.63) | ||
| T-cell count (×10 9 /L) | 1.79 (0.53,7.54) | 0.378 | ||
| Mean (SD) | 1.01 (0.49) | 1.16 (0.57) | ||
| Median (IQR) | 0.83 (0.70, 1.33) | 1.03 (0.80, 1.33) | ||
| Th-cell count (×10 9 /L) | 4.61 (0.35,98.2) | 0.274 | ||
| Mean (SD) | 0.56 (0.23) | 0.65 (0.27) | ||
| Median (IQR) | 0.53 (0.42, 0.60) | 0.60 (0.45, 0.71) | ||
| Tc-cell count (×10 9 /L) | 1.65 (0.25,15.4) | 0.616 | ||
| Mean (SD) | 0.40 (0.28) | 0.45 (0.38) | ||
| Median (IQR) | 0.27 (0.21, 0.57) | 0.38 (0.19, 0.57) | ||
| CD4 + TCM (% of TL) | 1.12 (1.00,1.27) | 0.059 | ||
| Mean (SD) | 15.6 (6.1) | 19.5 (6.0) | ||
| Median (IQR) | 16.7 (12.0, 19.9) | 19.0 (14.6, 23.3) | ||
| CD4 + TEM (% of TL) | 0.75 (0.58,0.92) | 0.013 | ||
| Mean (SD) | 8.3 (4.7) | 5.0 (2.2) | ||
| Median (IQR) | 7.9 (4.9, 11.2) | 4.6 (2.9, 6.0) | ||
| CD4 + TN (% of TL) | 1.04 (0.95,1.15) | 0.453 | ||
| Mean (SD) | 12 (7) | 13 (7) | ||
| Median (IQR) | 9 (7, 15) | 14 (7, 19) | ||
| CD8 + TCM (% of TL) | 1.14 (0.89,1.53) | 0.324 | ||
| Mean (SD) | 4.10 (2.03) | 4.96 (3.09) | ||
| Median (IQR) | 3.50 (2.85, 5.34) | 4.87 (2.53, 5.85) | ||
| CD8 + TEM (% of TL) | 1.07 (0.74,1.60) | 0.741 | ||
| Mean (SD) | 1.89 (1.34) | 2.07 (1.95) | ||
| Median (IQR) | 1.63 (0.71, 2.61) | 1.57 (0.59, 2.84) | ||
| CD8 + TN (% of TL) | 1.01 (0.82,1.26) | 0.934 | ||
| Mean (SD) | 5.8 (3.4) | 5.9 (2.9) | ||
| Median (IQR) | 5.4 (2.6, 7.8) | 5.3 (4.3, 6.9) | ||
| γδ T-cell count (×10 6 /L) | 1.00 (0.99,1.01) | 0.992 | ||
| Mean (SD) | 52 (55) | 52 (46) | ||
| Median (IQR) | 27 (11, 86) | 36 (18, 68) | ||
| B-cell count (×10 9 /L) | 0.54 (0.02,1.71) | 0.414 | ||
| Mean (SD) | 0.34 (0.98) | 0.15 (0.10) | ||
| Median (IQR) | 0.08 (0.06, 0.13) | 0.11 (0.08, 0.18) | ||
| Treg count (×10 6 /L) | 1.02 (0.98,1.06) | 0.435 | ||
| Mean (SD) | 32 (18) | 36 (17) | ||
| Median (IQR) | 24 (21, 35) | 34 (21, 43) | ||
| NK-cell count (×10 9 /L) | 1.11 (0.12,13.4) | 0.927 | ||
| Mean (SD) | 0.33 (0.36) | 0.34 (0.22) | ||
| Median (IQR) | 0.21 (0.12, 0.35) | 0.30 (0.16, 0.42) | ||
| NKT-like cell count (×10 9 /L) | 7.13 (0.03,6,502) | 0.521 | ||
| Mean (SD) | 0.11 (0.07) | 0.13 (0.13) | ||
| Median (IQR) | 0.10 (0.05, 0.19) | 0.09 (0.05, 0.21) | ||
| CD28 + ICOS + T cells (% of TL) | 1.02 (0.97,1.09) | 0.486 | ||
| Mean (SD) | 8 (11) | 11 (13) | ||
| Median (IQR) | 6 (1, 9) | 7 (1, 16) | ||
| Unknown | 0 | 2 | ||
| CD28 + ICOS- T cells (% of TL) | 0.99 (0.94,1.05) | 0.789 | ||
| Mean (SD) | 19 (12) | 18 (13) | ||
| Median (IQR) | 18 (11, 30) | 18 (8, 26) | ||
| Unknown | 0 | 2 |
Abbreviations OR – odds ratio, nDC – no disease control, DC – disease control, WBC, white blood count; ALC, absolute lymphocyte count; NLR, neutrophil-to-lymphocyte ratio; ALC, lymphocyte-to-monocyte ratio; TL, total lymphocytes; Th cells, helper T cells; Tc cells, cytotoxic T cells; TCM, central memory T-cells; TEM, effector memory T-cells; TN, naïve T-cells; Treg, regulatory T-cells; NK, natural killers; NKT-like, natural killers-like T-cells; MDSCs, myeloid-derived suppressor cells; ICOS, inducible T-cell costimulator