Table 3.
Association of early-on changes in peripheral blood circulating immune subsets with disease control rate
| nDC, N = 16 | DC, N = 25 | aOR (95% CI) | p-value | |
|---|---|---|---|---|
| ΔWBC (×10 9 /L) | 1.03 (0.58,1.82) | 0.923 | ||
| Mean (SD) | -0.13 (0.76) | -0.25 (1.78) | ||
| Median (IQR) | -0.36 (-0.66, 0.32) | 0.02 (-1.37, 0.62) | ||
| ΔNeutrophil count (×10 9 /L) | 0.98 (0.52,1.87) | 0.954 | ||
| Mean (SD) | -0.09 (0.64) | -0.20 (1.48) | ||
| Median (IQR) | -0.05 (-0.56, 0.45) | -0.20 (-1.00, 0.61) | ||
| ΔALC (×10 9 /L) | 0.78 (0.08,7.39) | 0.823 | ||
| Mean (SD) | -0.01 (0.23) | -0.02 (0.37) | ||
| Median (IQR) | 0.02 (-0.08, 0.04) | -0.10 (-0.19, 0.22) | ||
| ΔNLR | 1.01 (0.45,2.27) | 0.982 | ||
| Mean (SD) | -0.13 (0.56) | -0.08 (0.96) | ||
| Median (IQR) | -0.07 (-0.28, 0.12) | 0.09 (-0.57, 0.33) | ||
| ΔLMR | 0.78 (0.29,2.02) | 0.606 | ||
| Mean (SD) | 0.12 (0.53) | 0.05 (0.79) | ||
| Median (IQR) | 0.16 (-0.03, 0.42) | -0.13 (-0.43, 0.36) | ||
| ΔMDSC count (×10 9 /L) | 7.04 (0.06,1,291) | 0.424 | ||
| Mean (SD) | -0.05 (0.12) | -0.04 (0.18) | ||
| Median (IQR) | -0.05 (-0.11, 0.02) | -0.03 (-0.06, 0.08) | ||
| ΔT-cell count (×10 9 /L) | 5.01 (0.11,367) | 0.422 | ||
| Mean (SD) | 0.01 (0.16) | 0.02 (0.23) | ||
| Median (IQR) | -0.01 (-0.04, 0.06) | 0.04 (-0.09, 0.17) | ||
| ΔTh-cell count (×10 9 /L) | 73.7 (0.17,121,393) | 0.201 | ||
| Mean (SD) | 0.00 (0.10) | 0.04 (0.13) | ||
| Median (IQR) | -0.03 (-0.05, 0.04) | 0.02 (-0.04, 0.12) | ||
| ΔTc-cell count (×10 9 /L) | 0.04 (0.00,117) | 0.440 | ||
| Mean (SD) | 0.01 (0.06) | -0.02 (0.12) | ||
| Median (IQR) | 0.01 (-0.01, 0.03) | -0.01 (-0.09, 0.05) | ||
| ΔCD4 + TCM (% of TL) | 1.03 (0.83,1.29) | 0.791 | ||
| Mean (SD) | 0.7 (3.0) | 0.5 (3.5) | ||
| Median (IQR) | 0.4 (-1.0, 1.4) | 1.0 (-1.3, 2.5) | ||
| ΔCD4 + TEM (% of TL) | 0.68 (0.37,1.12) | 0.174 | ||
| Mean (SD) | 0.69 (2.21) | -0.14 (1.19) | ||
| Median (IQR) | 0.38 (-0.42, 1.27) | -0.07 (-0.74, 0.31) | ||
| ΔCD4 + TN (% of TL) | 1.75 (1.24,2.92) | 0.008 | ||
| Mean (SD) | -1.9 (2.9) | 1.1 (3.3) | ||
| Median (IQR) | -1.5 (-2.6, -0.9) | 0.8 (0.0, 3.4) | ||
| ΔCD8 + TCM (% of TL) | 0.78 (0.45,1.27) | 0.337 | ||
| Mean (SD) | 0.47 (1.37) | 0.05 (1.39) | ||
| Median (IQR) | 0.03 (-0.31, 0.69) | 0.16 (-0.44, 0.45) | ||
| ΔCD8 + TEM (% of TL) | 0.89 (0.42,1.92) | 0.754 | ||
| Mean (SD) | 0.21 (0.38) | 0.12 (1.09) | ||
| Median (IQR) | 0.13 (-0.01, 0.53) | -0.13 (-0.28, 0.13) | ||
| ΔCD8 + TN (% of TL) | 1.24 (0.78,2.16) | 0.393 | ||
| Mean (SD) | -0.35 (1.25) | 0.02 (1.63) | ||
| Median (IQR) | -0.32 (-0.78, 0.23) | 0.16 (-0.55, 0.63) | ||
| Δγδ T-cell count (×10 6 /L) | 1.01 (0.98,1.04) | 0.656 | ||
| Mean (SD) | -4 (12) | 0 (33) | ||
| Median (IQR) | -2 (-6, 1) | -2 (-9, 4) | ||
| ΔB-cell count (×10 9 /L) | 0.58 (0.00,2,254,543) | 0.943 | ||
| Mean (SD) | -0.01 (0.03) | -0.01 (0.05) | ||
| Median (IQR) | -0.01 (-0.02, 0.02) | 0.00 (-0.04, 0.02) | ||
| ΔTreg count (×10 6 /L) | 1.10 (1.03,1.21) | 0.012 | ||
| Mean (SD) | -1 (11) | 8 (13) | ||
| Median (IQR) | 0 (-9, 10) | 7 (1, 16) | ||
| ΔNK-cell count (×10 9 /L) | 0.21 (0.00,797) | 0.706 | ||
| Mean (SD) | -0.01 (0.09) | -0.02 (0.11) | ||
| Median (IQR) | 0.00 (-0.04, 0.04) | -0.02 (-0.07, 0.04) | ||
| ΔNKT-like cell count (×10 9 /L) | 0.00 (0.00,14.8) | 0.150 | ||
| Mean (SD) | 0.02 (0.03) | -0.01 (0.06) | ||
| Median (IQR) | 0.01 (0.00, 0.02) | -0.01 (-0.04, 0.01) | ||
| ΔCD28 + ICOS + T cells (% of TL) | 0.94 (0.82,1.06) | 0.340 | ||
| Mean (SD) | -2 (13) | -6 (13) | ||
| Median (IQR) | 1 (0, 3) | 0 (-6, 1) | ||
| Unknown | 0 | 2 | ||
| ΔCD28 + ICOS- T cells (% of TL) | 1.17 (1.05,1.34) | 0.012 | ||
| Mean (SD) | -2 (11) | 5 (11) | ||
| Median (IQR) | -7 (-9, 1) | 6 (-1, 10) | ||
| Unknown | 0 | 2 |
Abbreviations aOR – adjusted odds ratio for baseline level, nDC – no disease control, DC – disease control, WBC, white blood count; ALC, absolute lymphocyte count; NLR, neutrophil-to-lymphocyte ratio; ALC, lymphocyte-to-monocyte ratio; TL, total lymphocytes; Th cells, helper T cells; Tc cells, cytotoxic T cells; TCM, central memory T-cells; TEM, effector memory T-cells; TN, naïve T-cells; Treg, regulatory T-cells; NK, natural killers; NKT-like, natural killers-like T-cells; MDSCs, myeloid-derived suppressor cells; ICOS, inducible T-cell costimulator; Δ – the absolute value of difference