FIG. 1.

Production of nitrate/nitrite in segments of rat aortas during 24 h of incubation, as measured with Griess reagent. LPS alone (filled bar) increased the amount of nitrate/nitrite production compared to the control (Ctrl). Compared to that induced by LPS alone, the production of nitrate/nitrite was lower in segments coincubated with the peptides at 2 μM (*). However, fragment 106 was less effective at inhibiting nitrate/nitrate production than LL-37 at 2 μM (#). The data were analyzed by one-way repeated-measurement ANOVA followed by post hoc testing by the Holm-Sidak method (P < 0.05). Values are means + SEM (n = 7).