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. 2005 Jul;49(7):2845–2850. doi: 10.1128/AAC.49.7.2845-2850.2005

FIG. 4.

FIG. 4.

Chemotaxis of human neutrophils in response to LL-37, fragments 106 and 110, the 18-mer LLKKK, and the classical chemoattractant formyl peptide, fMLP. fMLP (0.1 μM) displayed a statistically significant chemoattractant activity (filled bar, §) compared to the control (open bar) (Student's paired t test; P < 0.05). The concentration-response curve for LL-37 was biphasic, with statistically significant chemoattractant activities at 0.1 and 1 μM but not at 10 μM (•,*). The concentration-response curves for fragments 106 (▪) and 110 (□) as well as that for the 18-mer LLKKK (▴) were similar to that of LL-37, except that at 10 μM, the 18-mer LLKKK induced a larger chemotactic response than that induced by LL-37 (#). The data were analyzed by two-way repeated-measurement ANOVA for the factors of different peptides and peptide concentrations followed by post hoc testing by the Holm-Sidak method (P < 0.05). Values are means ± SEM (n = 4).