TABLE 2.
Demographic and clinical parameters of patients with BSI due to Proteus mirabilis strains and differences between ESBL-P-PM and ESBL-N-PM isolates
| Demographic and clinical parameters | No. (%) of patientsa
|
P valueb | |
|---|---|---|---|
| ESBL-P-PM | ESBL-N-PM | ||
| No. of BSI patients | 9c | 14 | ND |
| No. of BSI episodes | 11c | 14 | ND |
| Age (yr) (mean ± SD) | 70.9 ± 17.5 | 67.3 ± 18.2 | NS |
| Sex (male/female) | 7/2 | 7/7 | ND |
| McCabe and Jackson groupsd | |||
| Nonfatal | 5 (55.6) | 8 (57.1) | NS |
| Ultimately fatal | 3 (33.3) | 4 (28.6) | NS |
| Rapidly fatal | 1 (11.1) | 2 (14.3) | NS |
| Charlson weighted index (mean ± SD)e | 4.0 ± 2.5 | 4.1 ± 2.6 | NS |
| Severity of septicemia | |||
| Sepsis | 6 (66.7) | 11 (78.6) | NS |
| Severe sepsis | 2 (22.2) | 2 (14.3) | NS |
| Septic shock | 1 (11.1) | 1 (7.1) | NS |
| Previous hospitalizations (during the last 12 months) | 6 (66.7) | 8 (57.1) | NS |
| Previous hospitalization in nursing home | 5 (55.6) | 3 (21.4) | 0.04 |
| Hospital-acquired BSI | 3 (33.3) | 6 (42.9) | NS |
| Hospital stay before BSI diagnosis (days) (mean ± SD) | 16.8 ± 30.3 | 6.0 ± 6.9 | 0.10 |
| Length of hospital stay (days) (mean ± SD) | 86.2 ± 193.4 | 19.4 ± 8.0 | 0.10 |
| Empirical treatment | |||
| Provided | 9 (100.0) | 12 (85.7) | NS |
| Adequate | 5 (55.6) | 12 (85.7) | 0.04 |
| Adequate treatment after ID/AST results | 4 (44.4) | 12 (85.7) | 0.04 |
| Predisposing factors | |||
| Bladder catheter | 9 (100.0) | 8 (57.1) | 0.01 |
| Previous use of antibiotics | 4 (44.4) | 3 (21.4) | 0.09 |
| Intravascular catheter | 4 (44.4) | 3 (21.4) | 0.09 |
| Corticosteroids or antineoplastic therapy | 2 (22.2) | 4 (28.6) | NS |
| Previous surgery | 0 (0.0) | 3 (21.4) | NS |
| Drainages | 0 (0.0) | 3 (21.4) | NS |
| Intubation | 1 (11.1) | 1 (7.1) | NS |
| Secondary BSI | |||
| All patients | 4 (44.4) | 3 (21.4) | 0.09 |
| Urinary tract | 4 (44.4)f | 3 (21.4)g | 0.09 |
| Other | 0 (0.0) | 0 (0.0) | NS |
| Overall mortality | 3 (33.3) | 2 (14.3) | NS |
| Mortality attributable to BSI | 3 (33.3) | 0 (0.0) | 0.04 |
a
Data are number (%) of patients, unless otherwise indicated.
b
NS, not significant; ND, not determined.
c
One patient had three different BSI; therefore, statistical analysis was performed considering only 9 BSI patients.
d
McCabe and Jackson groups used to classify the severity of the underlying disease (22).
e
Comorbidity scores determined according to the Charlson weighted index (6).
f
Three from bladder catheter.
g
One from bladder catheter.