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. 2005 Jul;49(7):2954–2958. doi: 10.1128/AAC.49.7.2954-2958.2005

TABLE 3.

Inhibition of binding of Bocillin FL to PBPs by two beta-lactams

Drug E. faecalis strain IC50a (μg/ml)
MIC (μg/ml)
PBP1 PBP3 PBP4 PBP5
Ampicillin SEF96 1 0.5 0.25 >16 1
ATCC 29212 1 0.5 0.25 >16 1
SVR 250 2 0.5 1 >8 1
SVR 251 2 0.5 0.25 >8 1
SVR 34 2 0.5 4 >32 8
SVR 138 2 0.5 4 >32 8
SVR 1110 1 0.5 8 >32 16
SVR 1119 1 0.25 8 >32 16
Imipenem SEF96 0.5 0.25 0.25 >16 1
ATCC 29212 0.5 0.25 0.125 >16 1
SVR 250 1 0.5 0.25 >8 0.5
SVR 251 0.5 0.25 0.5 >8 0.5
SVR 34 0.5 0.25 4 >32 4
SVR 138 0.5 0.25 4 >32 4
SVR 1110 1 0.5 32 >32 32
SVR 1119 1 0.25 16 >32 32
a

IC50, concentration of unlabeled antibiotic which reduces binding of Bocillin FL to a PBP by more than 50%.