TABLE 3.
Inhibition of binding of Bocillin FL to PBPs by two beta-lactams
Drug | E. faecalis strain | IC50a (μg/ml)
|
MIC (μg/ml) | |||
---|---|---|---|---|---|---|
PBP1 | PBP3 | PBP4 | PBP5 | |||
Ampicillin | SEF96 | 1 | 0.5 | 0.25 | >16 | 1 |
ATCC 29212 | 1 | 0.5 | 0.25 | >16 | 1 | |
SVR 250 | 2 | 0.5 | 1 | >8 | 1 | |
SVR 251 | 2 | 0.5 | 0.25 | >8 | 1 | |
SVR 34 | 2 | 0.5 | 4 | >32 | 8 | |
SVR 138 | 2 | 0.5 | 4 | >32 | 8 | |
SVR 1110 | 1 | 0.5 | 8 | >32 | 16 | |
SVR 1119 | 1 | 0.25 | 8 | >32 | 16 | |
Imipenem | SEF96 | 0.5 | 0.25 | 0.25 | >16 | 1 |
ATCC 29212 | 0.5 | 0.25 | 0.125 | >16 | 1 | |
SVR 250 | 1 | 0.5 | 0.25 | >8 | 0.5 | |
SVR 251 | 0.5 | 0.25 | 0.5 | >8 | 0.5 | |
SVR 34 | 0.5 | 0.25 | 4 | >32 | 4 | |
SVR 138 | 0.5 | 0.25 | 4 | >32 | 4 | |
SVR 1110 | 1 | 0.5 | 32 | >32 | 32 | |
SVR 1119 | 1 | 0.25 | 16 | >32 | 32 |
IC50, concentration of unlabeled antibiotic which reduces binding of Bocillin FL to a PBP by more than 50%.